Background: We investigated the association between the polymorphisms of DNA repair genes, metabolic enzyme genes, and superficial bladder cancer to better understand the role of gene polymorphisms in bladder carcinogenesis for the Han-Chinese population in Shanghai.
Methods: The SNPs in the XPC, XPG, XRCC1, NQO2, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 genes were genotyped using the TaqMan Probe-based polymerase chain reaction.
Results: The AC + CC genotypes of XPC Lys939Gln and the CC genotype of XPG His1104Asp were more frequent in patients of superficial bladder cancer at the initial diagnosis (adjusted OR [95% CI], 1.89 [1.21-3.24]; adjusted OR [95% CI], 1.07 [0.86-1.87], respectively). The risk for carriers of the XPC-33512C allele increased after stratifying by smoking habits (adjusted OR [95% CI], 1.95 [0.56-6.09]). There was a significant trend for an increased carcinogenesis risk with an increasing number of putative high-risk alleles. We found no significant associations between any of the ten polymorphisms and clinicopathological features of superficial bladder cancer.
Conclusion: These results suggest that the polymorphism in XPC Lys939Gln may modulate superficial bladder cancer risk, and these effects may preferentially affect current smokers. The data also support the possibility of an increased risk for superficial bladder cancer in individuals with a higher number of genetic variations in DNA repair and metabolic enzyme genes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11255-009-9560-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neutrophils to lymphocytes ratio as a predictor of BCG response in non-muscle invasive bladder cancer.
Urologia
January 2025
Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Aim: To evaluate the role of preoperative neutrophils to lymphocytes ratio (NLR) as a predictor for the response to BCG in patients with non-muscle invasive bladder cancer (NMIBC).
Materials: Nighty six patients with NMIBC were prospectively included in our study. Our study population was classified into two groups, based on pre-operative (NLR) either ⩽ or > 3.
Benign Glomus Tumor of the Urinary Bladder: A Case Report and Literature Review.
Int J Surg Pathol
December 2024
Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Article Synopsis
- * Imaging tests revealed a significant mass in the left bladder and a nonfunctional right kidney, leading to surgical removal of both the kidney and part of the bladder.
- * The final diagnosis was a bladder glomus tumor, and the patient remains healthy with no signs of recurrence after 15 months, underscoring the need for urologists to consider glomus tumors in their diagnostic process.
Polyploid superficial uroepithelial bladder barrier cells express features of cellular senescence across the lifespan and are insensitive to senolytics.
Aging Cell
December 2024
Center on Aging, University of Connecticut, Farmington, Connecticut, USA.
Lower urinary tract dysfunction (LUTD) increases with aging. Ensuing symptoms including incontinence greatly impact quality of life, isolation, depression, and nursing home admission. The aging bladder is hypothesized to be central to this decline, however, it remains difficult to pinpoint a singular strong driver of aging-related bladder dysfunction.
View Article and Find Full Text PDFIFRD1 is required for maintenance of bladder epithelial homeostasis.
iScience
December 2024
Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
The maintenance of homeostasis and rapid regeneration of the urothelium following stress are critical for bladder function. Here, we identify a key role for IFRD1 in maintaining urothelial homeostasis in a mouse model. We demonstrate that the murine bladder expresses IFRD1 at homeostasis, particularly in the urothelium, and its loss alters the global transcriptome with significant accumulation of endolysosomes and dysregulated uroplakin expression pattern.
View Article and Find Full Text PDFArticle Synopsis
- * Most patients (69.2%) experienced pain due to infections or osteoarthritis, with various fracture types being treated through different surgical approaches, primarily the modified Stoppa.
- * Despite a mean follow-up of 11.3 months showing decreased pain levels (VAS score from 6 to 1), the procedure carried significant complication risks, with intraoperative (30.8%) and postoperative (38.5%) issues reported, highlighting the need for experienced surgical teams.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!