AI Article Synopsis
- This study examines the role of interleukin-6 (IL-6) gene G-174C polymorphism in affecting the risk of coronary artery disease (CAD), cardiovascular events, and mortality in patients undergoing chronic dialysis.
- It involved 463 chronic dialysis patients, revealing that those with the CC genotype had significantly poorer survival rates and faced more cardiovascular events compared to other genotypes.
- While the IL-6 gene polymorphism impacted patient outcomes, it did not influence the onset or progression of CAD itself, nor did it show differences in inflammatory markers like CRP and fibrinogen among genotypes.
Article Abstract
Background: Inflammation is a well recognized central component of atherosclerotic processes in chronic kidney disease. Interleukin-6 (IL-6) levels are a strong determinant of cardiovascular mortality in dialysis patients. We evaluated the impact of IL-6 gene G-174C polymorphism associated with modified IL-6 production on the development of coronary artery disease (CAD), cardiovascular events and mortality in chronic dialysis patients.
Methods: We studied n = 463 patients on chronic dialysis with angiographically confirmed (n = 218) or excluded (n = 245) CAD followed up for 65 months after initiation of dialysis. Monitored were arterial hypertension, diabetes mellitus, hyperlipidemia, smoking, CRP and fibrinogen. IL-6 gene G-174C polymorphism was determined by PCR amplification.
Results: The CC genotype was associated with an impaired patient survival (p < 0.05) remaining an independent risk factor for death in multivariate analysis (HR for CC genotype: 3.58, CI: 1.41-9.07, p < 0.01). CC genotype carrying CAD patients suffered significant frequently cardiovascular events (revascularization, myocardial infarction, death) compared to GG/GC genotype carriers (85.2% vs. 66.5, p < 0.05). However, the IL-6 gene G-174C polymorphism was not related to the onset and development of CAD itself (ns) and the inflammation parameters CRP and fibrinogen did not differ between the genotypes under investigation (ns).
Conclusions: Our results suggest that IL-6 gene G-174C polymorphism is associated with the incidence of cardiovascular events and mortality in chronic dialysis patients.
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| http://dx.doi.org/10.1093/ndt/gfp141 | DOI Listing |
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