Osteoarthritis (OA) is the most common articular disease of the developed world and a leading cause of chronic disability, mostly as a consequence of the knee OA and/or hip OA. In spite of misrecognition of the exact cause, a number of studies have shown that obesity represents one of the most important risk factors and it is also a predictor for progression of OA, especially of a knee joint and less of the hip joint. Relationship between body mass index (BMI) and OA of the knee is mainly linear, and duration of increasedjoint loading or gaining weight is also significant. Studies about obesity and hand OA are contradictory. Risk gradient for BMI and the hip OA is somewhere between the knee and the hand gradient. Disability may be significantly relieved if a body weight is decreased for more than 5.1%. Twenty seven percent of cases of hip arthroplasty and 69% knee arthroplasty may be attributed to obesity. Nonpharmacologic treatment of OA includes treatment of obesity.
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Surg Obes Relat Dis
February 2025
Department of Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address:
Background: There is no gold standard for recurrent weight gain following Roux-en-Y gastric bypass (RYGB). Combining jejuno-jejunostomy distalization type 1 (JJD1) and sleeve resection of the gastrojejunostomy and gastric pouch (GJ-P) may be a potential approach for these patients.
Objectives: To describe 1-year perioperative and nutritional outcomes of patients who underwent JJD1 with sleeve resection of the GJ-P.
Nutr Metab Cardiovasc Dis
February 2025
Division of Sports Medicine and Science, Graduate School of Physical Education, Kyung Hee University, Yongin, 17104, Republic of Korea; Obesity and Physical Activity Research Laboratory, Kyung Hee University, Yongin, 17104, Republic of Korea. Electronic address:
Background And Aim: We investigated the effects of brief, intense stair climbing on cardiorespiratory fitness (CRF) and cardiometabolic risk factors in young Korean men with obesity.
Methods And Results: Twenty-four healthy men (age: 25.8 ± 2.
Food Res Int
April 2025
College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China; Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing 314100, China. Electronic address:
Lipid accumulation and metabolic disorders caused by a high-fat diet (HFD) pose significant threats to human health, and place a substantial burden on individuals and society. In this study, a novel combination comprising three traditional Chinese herbs (lotus leaf, hawthorn, and leaf of Chinese holly) and a probiotic (Bifidobacterium lactis BPL-1) (TCMP) was prepared. Then, its effects on growth performance, fat accumulation, hepatic function and gut microbiota in mice fed a high-fat diet were investigated.
View Article and Find Full Text PDFBrain Res Bull
March 2025
Laboratory of Neuroscience, Department of Psychology, University of Oviedo, Oviedo, Spain; Institute of Neurosciences of the Principality of Asturias (INEUROPA), Oviedo, Spain; Health Research Institute of the Principality of Asturias (ISPA), Oviedo, Spain. Electronic address:
The global rise in obesity and poor dietary habits, particularly the consumption of high-fat, high-sucrose (HFS) diets, is a growing public health concern. These diets, especially when consumed during critical developmental periods, such as gestation and early life, are linked to long-term consequences on both physical and mental health. Early exposure to obesogenic diets has been shown to disrupts brain function and increases the risk of anxiety, depression, and additional emotional disorders.
View Article and Find Full Text PDFEnviron Res
March 2025
Department Clinical Pharmacology, Pharmacy and Environmental Medicine, Institute of Public Health, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark; Hans Christian Andersen Children's Hospital, Odense University Hospital, Kløvervænget 23C, 5000, Odense C, Denmark; Open Patient data Explorative Network, Odense University Hospital, J. B. Winsløws Vej 21, 3. sal, DK-5000 Odense, Denmark.
The global increase in childhood overweight and obesity presents significant public health concerns due to its long-term health implications. Emerging evidence suggests that exposure to endocrine disrupting chemicals, such as per- and polyfluoroalkylated substances (PFAS), may be obesogenic and contribute to adiposity. This study aimed to investigate the association between prenatal PFAS exposure and markers of adiposity in 7-year-old children, focusing on potential sex-specific differences.
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