AI Article Synopsis
- The study measured levels of platelet-derived microparticles (PDMP) in patients with polymyositis and dermatomyositis (PM/DM) using an ELISA method to investigate platelet activation.
- Active PM/DM patients showed significantly higher PDMP levels compared to both treated patients and healthy controls, indicating a potential role of platelets in the disease's inflammatory process.
- A reduction in PDMP levels was observed after glucocorticoid treatment, and significant correlation with serum C-reactive protein levels suggests PDMP could serve as a useful marker for monitoring inflammation in PM/DM patients.
Article Abstract
Platelet-derived microparticle (PDMP) levels were measured using an enzyme-linked immunosorbent assay (ELISA) to elucidate the role of platelet activation in patients with polymyositis or dermatomyositis (PM/DM). PDMP levels in active PM/DM patients (median 13.3 U/ml, interquartile range 9.9-20.7 U/ml, n = 16) and those in patients undergoing treatment (12.1 U/ml, 7.4-16.7 U/ml, n = 12) were significantly higher than in controls (6.5 U/ml, 5.0-8.4 U/ml, n = 26, vs. active, P = 0.0001; vs. treatment, P = 0.004). In a paired sampling study, PDMP decreased significantly after glucocorticoid treatment (P = 0.04). PDMP in the active PM/DM patients correlated significantly with serum C-reactive protein levels (r(s) = 0.67, P = 0.01). These results suggest that platelets may play an important role in the inflammatory process, and that PDMP level could be a useful marker of inflammatory activity in PM/DM patients. Muscle Nerve 39: 586-590, 2009.
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| http://dx.doi.org/10.1002/mus.21311 | DOI Listing |
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