AI Article Synopsis

  • The essential oils from Ridolfia segetum and Oenanthe crocata were tested for their effects on the HIV-1 reverse transcriptase (RT) enzyme, showing inhibition of RNA-dependent DNA polymerase activity in a dose-dependent manner, but no effect on ribonuclease H activity.
  • The oils were found to be cytotoxic to K (562) cells, indicating potential harmful effects on cell replication.
  • GC-MS analysis revealed that the main components of R. segetum included compounds like alpha-phellandrene and dillapiol, while O. crocata primarily contained sabinene and various types of ocimene.

Article Abstract

The essential oils of Ridolfia segetum (L.) Moris and Oenanthe crocata L. (Apiaceae), collected in Sardinia (Italy), have been assayed for two enzyme-associated activities of the HIV-1 reverse transcriptase (RT): RNA-dependent DNA polymerase (RDDP) activity and ribonuclease H (RNase H) activity. In biochemical assays, the essential oils inhibited HIV-1 RT RDDP activity in a dose-dependent manner, while they were inactive towards RNase H activity. Furthermore, the oils were cytotoxic towards K (562) cell replication. GC-MS analysis of the essential oils obtained by steam distillation of the aerial parts showed that the main components of R. segetum were alpha-phellandrene, alpha-terpinolene, beta-phellandrene, and dillapiol and those of O. crocata were sabinene, TRANS-beta-ocimene, CIS-beta-ocimene, and beta-pinene.

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Source
http://dx.doi.org/10.1055/s-0029-1185546DOI Listing

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