AI Article Synopsis
- The study aimed to see if diffusion tensor imaging can distinguish patients with long-term cognitive issues after mild traumatic brain injury (TBI) from healthy individuals.
- Results showed significantly lower fractional anisotropy (FA) and higher apparent diffusion coefficient (ADC) in a specific brain region (genu of the corpus callosum) for TBI patients, indicating potential white matter damage.
- The findings suggest that mild TBI can lead to lasting changes in brain structure that may contribute to ongoing cognitive problems, highlighting the need for more in-depth research.
Article Abstract
Objective: To determine if diffusion tensor imaging can differentiate patients with chronic cognitive impairment after mild traumatic brain injury (TBI) from normal controls.
Methods: Ten patients with persistent cognitive impairment after mild TBI were evaluated at least 2 years after injury. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured at white matter regions susceptible to axonal injury after TBI. Comparison was made to 10 normal controls.
Results: Fractional anisotropy was significantly lower (4.5%; P = 0.01) and ADC higher (7.1%; P = 0.04) in patients at the left side of the genu of the corpus callosum. The mild TBI group also demonstrated a significant increase in FA within the posterior limb of the internal capsule bilaterally (left, 5.1%; P = 0.03; right, 1.9%; P = 0.04).
Conclusions: These results demonstrate low FA and high ADC in the genu of the corpus callosum of mild TBI patients with persistent cognitive impairment, suggesting that permanent white matter ultrastructural damage occurs in mild TBI, and that such damage may be associated with persistent cognitive disability. Further longitudinal studies are warranted to elucidate the full importance of the findings.
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| http://dx.doi.org/10.1097/RCT.0b013e31817579d1 | DOI Listing |
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