In this article, we have discussed the possible causes of a longitudinal pigmented nail band. A thorough history, physical examination, and, when indicated, biopsy of the origin of the band should reassure the patient with a benign lesion and direct further treatment of a patient with a malignant or potentially malignant lesion.
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Association of dysfunctional adiposity index with kidney impairment is accounted for by pigment epithelium-derived factor in type 2 diabetes mellitus - An 11-year follow-up of the SMART2D cohort study.
J Diabetes Complications
January 2025
Clinical Research Unit, Khoo Teck Puat Hospital, Singapore; Diabetes Centre, Admiralty Medical Centre, Khoo Teck Puat Hospital, Singapore; Saw Swee Hock School of Public Health, National University Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address:
Aims: This novel longitudinal study investigated the association of the new dysfunctional adiposity index (DAI) with kidney impairment in multi-ethnic Asians with type 2 diabetes mellitus (T2DM), and the mediation effect of pigment epithelium-derived factor (PEDF).
Methods: T2DM adults followed for up to 10.5 years were analyzed (n = 1611).
Background/objectives: Adaptive optics ophthalmoscopy (AOO) has the potential to provide insights into AMD pathology and to assess the risk of progression. We aim to utilise AOO to describe detailed features of intermediate AMD and to characterise microscopic changes during atrophy development.
Subjects/methods: Patients with intermediate AMD were recruited into PINNACLE, a prospective observational cohort study.
From spots to stripes: Evolution of pigmentation patterns in monkeyflowers via modulation of a reaction-diffusion system and its prepatterns.
bioRxiv
January 2025
Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA.
The reaction-diffusion (RD) system is widely assumed to account for many complex, self-organized pigmentation patterns in natural organisms. However, the specific configurations of such RD networks and how RD systems interact with positional information (i.e.
View Article and Find Full Text PDFMacular Pigment Changes and Visual Recovery Following Successful Full-Thickness Macular Hole Closure Using the Inverted Flap Technique.
J Clin Med
January 2025
Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples "Federico II", 80131 Napoli, Italy.
: This study aimed to assess the role of macular pigment optical density (MPOD) in patients with a full-thickness macular hole (FTMH) compared to healthy controls, evaluating postoperative changes in MPOD and exploring potential correlations with visual outcomes. : This prospective, cross-sectional, comparative study included 16 eyes from FTMH patients who achieved anatomical hole closure following pars plana vitrectomy with the inverted ILM flap technique. Each eye underwent a comprehensive ophthalmologic examination, including BCVA and intraocular pressure measurements, anterior segment evaluation, fundus examination, and macular assessment with Enhanced Depth Imaging Optical Coherence Tomography (EDI-OCT, Spectralis, Heidelberg Engineering Inc.
View Article and Find Full Text PDFNeuroretinal and RPE changes and susceptibility to Age-Related Macular Degeneration: insights from the longitudinal Alienor Study.
Ophthalmology
January 2025
University of Bordeaux, INSERM, BPH, U1219, F-33000 Bordeaux, France; FRCRnet, F-CRIN network, France.
Purpose: We assessed the associations of macular layer thicknesses, measured using spectral-domain OCT (SD-OCT), with incident age-related macular degeneration (AMD) and AMD polygenic risk scores (PRS).
Design: Population-based cohort study PARTICIPANTS: 653 participants of the Alienor study, with biennial eye imaging from 2009 to 2024.
Methods: Macular layer thicknesses of eight distinct layers and three compound layers were automatically segmented based on SD-OCT imaging of the macula.
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