AI Article Synopsis
- Salivary gland oncocytic lipoadenoma is a rare benign tumor that combines mature fat tissue with oncocytic cells, and this report highlights a unique case with sebaceous differentiation.
- A 64-year-old male had a well-encapsulated tumor in his left parotid gland that measured 3.5 x 3 cm, showing both fat cells and distinct oncocytic changes in its epithelial components.
- Cytogenetic analysis revealed a translocation involving the HMGA2 gene, which is similar to changes seen in other salivary gland tumors such as lipomas and pleomorphic adenomas.
Article Abstract
Salivary gland oncocytic lipoadenoma is an exceptional benign tumor composed of mature adipose tissue associated with a mixture of oncocytes. We report a case of oncocytic lipoadenoma showing sebaceous differentiation, and provide a cytogenetic analysis, which has not yet been described. A 64-year-old male developed a left parotid gland, well-encapsulated tumor measuring 3.5 x 3 cm(2), showing mature fat cells associated with oncocytic changes of epithelial components. Immunohistochemistry showed a dual epithelial population with ductal (positivity for AE1/AE3, CK19, CK7 antibodies) and basal-cell (positivity for p63, CK14, CK5,6 antibodies) differentiation in oncocytic areas. Moreover, oncocytic cells were stained with anti-alpha-1 antichymotrypsin antibody and phosphotungstic acid-hematoxylin staining. Molecular cytogenetic analysis showed a translocation t(12;14), resulting in structural rearrangement of the region framing the HMGA2 gene at 12q14.3. Such alterations in HMGA2 have been described in both lipomas and pleomorphic adenomas of the salivary glands.
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| http://dx.doi.org/10.1016/j.prp.2009.02.008 | DOI Listing |
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