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The antibacterial activity of Magainin I immobilized onto mixed thiols Self-Assembled Monolayers. | LitMetric

The antibacterial activity of Magainin I immobilized onto mixed thiols Self-Assembled Monolayers.

Biomaterials

CNRS, UMR CNRS 7197, Laboratoire de Réactivité de Surface, 4 Place Jussieu, 75252 Paris Cedex 05, France.

Published: July 2009

AI Article Synopsis

  • Researchers attached the antibacterial peptide Magainin I to a gold surface using a specific chemical mix and characterized the process using advanced spectroscopy techniques.
  • The effectiveness of the Magainin I against three types of Gram-positive bacteria showed a significant reduction in bacterial adhesion and killing of those that did adhere.
  • The study found no release of the peptide during testing, indicating it maintained its antibacterial properties for up to six months after application.

Article Abstract

An antibacterial peptide, Magainin I, was covalently bound to a mixed 11-mercaptoundecanoïc acid (MUA) and 6-mercaptohexanol (C6OH) (ratio 1:3) Self-Assembled Monolayer (SAM) on gold surfaces. Each step of the surface functionalization was characterized by Polarization Modulation Reflection Absorption InfraRed Spectroscopy (PM-RAIRS) and X-ray Photoelectron Spectroscopy (XPS). The antibacterial activity of the anchored Magainin was tested against three Gram-positive bacteria (Listeria ivanovii, Enterococcus faecalis and Staphylococcus aureus), and the results revealed that the adsorbed Magainin I reduced by more than 50% the adhesion of bacteria at the surface, together with the killing of the bacteria that nonetheless adhered to the surface. No release of the peptide was observed upon contact with the bacterial suspension; the activity has proven to be persistent overtime, up to six months after the first use.

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Source
http://dx.doi.org/10.1016/j.biomaterials.2009.03.025DOI Listing

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