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The Evolution of Treatment-Free Remission.
Blood
January 2025
South Australian Health & Medical Research Institute, Australia.
One of the most remarkable achievements of the TKI era has been the capacity to induce deep molecular remissions that are sustainable off therapy in chronic myeloid leukemia (CML) patients - treatment-free remission (TFR). TFR was first described in a handful of patients within 3-4 years of imatinib approval. In 2004 TFR was tested in a small French pilot study, followed soon after by the French STIM and Australasian TWISTER studies.
View Article and Find Full Text PDFAN UPDATED OVERVIEW OF ORTHOGNATHIC SURGERY PRACTICES IN FRANCE.
J Stomatol Oral Maxillofac Surg
December 2024
Maxillo-facial Surgery Department, Hôpital Lyon Sud, Hospices Civil de Lyon, Hôpital Lyon Sud, Lyon Pierre Bénite, France.
Introduction: Orthognathic surgery is a fundamental component of a maxillofacial surgeon's practice. In France, 510 specialists actively practice oral and maxillofacial surgery. In OMFs, despite the existence of evidence-based recommendation that address diagnosis, treatment planning, and operating methods, each surgeon/institution has developed an individual approach towards clinical management.
View Article and Find Full Text PDFEngraft: A Collaborative Learning Health Network for Enhanced Transplant and Cellular Therapy Outcomes.
Transplant Cell Ther
December 2024
University of Cincinnati College of Medicine, Cincinnati, Ohio; James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
The Engraft Learning Health Network (LHN) aims to improve outcomes for patients undergoing transplant and cellular therapy (TCT) through a collaborative, data-driven approach. Engraft brings together diverse stakeholders, including clinicians, patients, caregivers, and institutions, to standardize best practices and accelerate the dissemination of innovations in TCT care. By establishing a multicenter, real-world clinical registry focused on rapid-cycle quality improvement (QI) and implementation research, Engraft seeks to reduce variability in clinical practice to improve TCT outcomes across centers.
View Article and Find Full Text PDFPrevalence and associated factors of non-consensual sexual acts among adolescents in the Democratic Republic of Congo.
Front Reprod Health
December 2024
CORDAID, Kinshasa, Democratic Republic of Congo.
Introduction: During adolescence, due to lack of experience, individuals may engage in or tolerate certain non-consensual acts under coercion. There are significant associations between forced sexual intercourse and a range of negative effects on reproductive health, as well as psychological and emotional health. Studies on non-consensual sexual acts among adolescents are rare in the Democratic Republic of Congo (DRC).
View Article and Find Full Text PDFAn expert consensus statement on biomarkers of ageing for use in intervention studies.
J Gerontol A Biol Sci Med Sci
December 2024
Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method.
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