Purpose: First dorsal compartment anatomy was analyzed for the presence of a separate compartment for the extensor pollicis brevis (EPB) tendon and the ability of the EPB to extend the thumb interphalangeal (IP) joint in order to determine if these characteristics were associated with each other, and with de Quervain's disease.
Methods: Two groups were studied: (1) 90 cadaver wrists, 28 to 89 years, 38 male and 52 female specimens; and (2) 143 patient wrists, 21 to 82 years, 18 men and 125 women, in which the first dorsal compartment was released for treatment of de Quervain's disease.
Results: The EPB was in a separate compartment in 102 of 143 of the surgical group and 18 of 90 of the cadaver group. The EPB was able to extend the IP joint in 56 of 143 of the surgical group and 19 of 90 of the cadaver group. When the EPB was able to extend the IP joint, it was in a subcompartment in 49 of 56 of the surgical group and 9 of 19 of the cadaver group. When the EPB was able to produce IP extension in the cadaver group, it was inserted on the distal phalanx or the extensor hood.
Conclusions: In a substantial number of people undergoing surgery for de Quervain's disease and in cadavers, the EPB can extend the thumb IP joint. When it does, particularly in patients with de Quervain's disease, it is likely to reside in a subcompartment of the first dorsal compartment. The incidences of a subcompartment for the EPB and the ability of the EPB to extend the thumb IP joint were higher in the de Quervain's patient population than in the cadaver group.
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http://dx.doi.org/10.1016/j.jhsa.2008.12.015 | DOI Listing |
Sci Rep
May 2024
Division of Nephrology, Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea.
Urinary tract infection (UTI) is the most prevalent urological condition worldwide. Choosing appropriate antibiotics for patients who have fever before receiving a culture result is challenging. This retrospective study enrolled patients 394 patients hospitalized at Gangneung Asan Hospital for UTI from May 2017 to April 2021.
View Article and Find Full Text PDFNeurol Neuroimmunol Neuroinflamm
July 2024
From the Division of Infectious Diseases and Immunology (M.S.W.Q., C.V., A.M.C.R.), Department of Pediatrics, Erasmus MC University Medical Center-Sophia Children's Hospital; Department of Neurology (M.S.J.B., M.J.T., R.F.N.); Department of Clinical Genetics (V.J.M.V.), Erasmus MC University Medical Center, Rotterdam; Pediatric Stem Cell Transplantation Program (E.P.B.), Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center; Division Gastroenterology and Nutrition (M.H., J.N.S.), Department of Pediatrics/Laboratory of Pediatrics, Erasmus MC University Medical Center; and Division of Rheumatology (S.K.), Department of Pediatrics, Erasmus MC University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
Objectives: We report on the therapeutic management of early-onset severe neurologic symptoms in cytotoxic T lymphocyte antigen-4 haploinsufficiency (CTLA-4h) and the presence of antibodies to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) as an important finding.
Methods: This is a case report from a Dutch academic hospital. Repeated clinical examinations, repeated brain MRI and extended diagnostics on serum and CSF were performed.
Antibiotics (Basel)
September 2022
Pathogen Genomics Center, National Institute of Infectious Diseases, Shinjyuku-ku, Tokyo 162-8640, Japan.
Nat Chem Biol
February 2023
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Nat Commun
October 2022
Immunoglobulin Research Laboratory, Department of Experimental Immunohematology, Sanquin Research and Landsteiner, Amsterdam UMC, University of Amsterdam, 1066 CX, Amsterdam, The Netherlands.
Binding to the neonatal Fc receptor (FcRn) extends serum half-life of IgG, and antagonizing this interaction is a promising therapeutic approach in IgG-mediated autoimmune diseases. Fc-MST-HN, designed for enhanced FcRn binding capacity, has not been evaluated in the context of a full-length antibody, and the structural properties of the attached Fab regions might affect the FcRn-mediated intracellular trafficking pathway. Here we present a comprehensive comparative analysis of the IgG salvage pathway between two full-size IgG1 variants, containing wild type and MST-HN Fc fragments, and their Fc-only counterparts.
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