AI Article Synopsis
- In cell biology, various microscopy techniques like light and electron microscopy are essential for studying cellular structure and function, but no single method can provide all the necessary information.* -
- Multiple imaging techniques have been developed, each offering unique insights, and the most effective studies use a combination of these methods across different spatial scales while maintaining the cell's hydrated state.* -
- Correlative microscopy involves using complementary techniques to analyze a larger cell population, identify key features, and then take high-resolution images that reflect real cellular processes.*
Article Abstract
In cell biology, visual techniques such as light and electron microscopy provide the most intuitive means by which to study structure and function; however, no single microscopy technique is capable of providing all of the desired information. As a consequence, many separate techniques have evolved, each with unique capabilities. The most informative approaches are global in the sense that they take advantage of multiple imaging modalities spanning a range of spatial scales and frequencies, preferably encompassing preservation of the hydrated nature of the cell. Correlative microscopy utilizes complementary visual techniques that allow the experimenter to capture significant proportions of a population of cells, to identify features of interest, and to then capture high-resolution snapshots that represent bona fide cellular events.
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| http://dx.doi.org/10.1016/j.copbio.2009.03.008 | DOI Listing |
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