Nodular regenerative hyperplasia of the liver, characterised by regenerative nodules distributed throughout the liver in the absence of fibrosis, is a rare but important complication of systemic lupus erythematosus. The main consequence of nodular regenerative hyperplasia of the liver is non-cirrhotic portal hypertension. This condition is probably underdiagnosed, as many of these patients may remain asymptomatic. Furthermore, nodular regenerative hyperplasia of the liver may be misdiagnosed as cirrhosis. We describe three female patients with nodular regenerative hyperplasia of the liver associated with systemic lupus erythematosus. All three patients have clinical manifestations of portal hypertension, and all were initially misdiagnosed as having cryptogenic cirrhosis.
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Article Synopsis
- The study examines patients with nodular regenerative hyperplasia, focusing on their clinical and histopathological features, as well as comparing results with existing literature.
- Out of 82 patients, 45% had signs of portal hypertension at diagnosis, while 33% were diagnosed incidentally during other procedures.
- The research found that patients diagnosed incidentally had fewer liver-related complications and were more likely to have associated conditions compared to those diagnosed by clinical suspicion.
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