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Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior. | LitMetric

AI Article Synopsis

  • Midbrain dopamine neurons operate in two main modes, tonic and phasic, which influence different behavioral outcomes, but selectively disrupting these has been challenging.
  • Researchers investigated the specific role of phasic dopamine by blocking burst firing and dopamine release without affecting tonic activity, using genetic methods to inactivate certain receptors in dopamine neurons.
  • The findings revealed that disrupting phasic dopamine impaired learning related to reward and punishment cues, but many other dopamine-related behaviors remained unchanged.

Article Abstract

Midbrain dopamine (DA) neurons fire in 2 characteristic modes, tonic and phasic, which are thought to modulate distinct aspects of behavior. However, the inability to selectively disrupt these patterns of activity has hampered the precise definition of the function of these modes of signaling. Here, we addressed the role of phasic DA in learning and other DA-dependent behaviors by attenuating DA neuron burst firing and subsequent DA release, without altering tonic neural activity. Disruption of phasic DA was achieved by selective genetic inactivation of NMDA-type, ionotropic glutamate receptors in DA neurons. Disruption of phasic DA neuron activity impaired the acquisition of numerous conditioned behavioral responses, and dramatically attenuated learning about cues that predicted rewarding and aversive events while leaving many other DA-dependent behaviors unaffected.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678650PMC
http://dx.doi.org/10.1073/pnas.0813415106DOI Listing

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