A 46-year-old man was assaulted with a club to the face, chest and abdomen. On admission there were no signs of circulatory shock. The abdominal examination was unremarkable. During his stay in hospital he had light diets. He was managed symptomatically and discharged 5 days after the incident. Two hours after discharge he was admitted again with a complain of severe abdominal pain. Immediately after a heavy diet, he experienced this abdominal pain. On admission, he was pale with features of circulatory shock. There was a marked tenderness with rigidity and guarding on abdominal palpation. Without a proper diagnosis he was pronounced dead 13 h after admission. Autopsy revealed a haemoperitoneum. A haematoma was seen overlying a splenic laceration on the gastric area of the visceral surface. The body of the empty stomach was in contact with this haematoma. Histological examination confirmed the perisplenic haematoma of otherwise normal spleen. The pressure exerted by full stomach after heavy solid meals may disturb perisplenic haematoma overlying a laceration on the gastric surface of the spleen causing delayed splenic rupture leading to sudden fatal intraperitoneal haemorrhage.
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http://dx.doi.org/10.1016/j.legalmed.2009.02.069 | DOI Listing |
Immunotargets Ther
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CNRS UPR3572, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg, 67084, France.
Purpose: The co-inhibitory receptor B and T Lymphocyte Attenuator (BTLA) negatively regulates B and T cell activation. We have previously shown an altered BTLA expression by regulatory T cells and an impaired capacity of BTLA to inhibit CD4 T cell activation in lupus patients. In this study, we analyzed BTLA expression and function in the NZB/W lupus-mouse model and examined the therapeutic potential of BTLA targeting.
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January 2025
Department of Pediatric Surgery, Mohamed VI University Hospital, Faculty of Medicine and Pharmacy, Abdelmalek Essaâdi University, Tetouan, Morocco.
Introduction: Tuberculosis remains a major public health problem in developing countries. Isolated splenic tuberculosis is a rare form of extrapulmonary tuberculosis, with few cases documented in the literature, occurring mainly in immunocompromised individuals. The purpose of this article is to contribute to the medical knowledge regarding this rare disease and to highlight the diagnostic challenges and management approach.
View Article and Find Full Text PDFData Brief
February 2025
Department of Child Health, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta 10430, Indonesia.
Glycogen storage disease type IV (GSD IV) is a rare disease caused by a defect in glycogen branching enzyme 1 (GBE1), which played a crucial role in glycogen branching. GSD IV occurs once in approximately 1 in every 760,000 to 960,000 live births and is inherited in an autosomal recessive pattern. Early diagnosis of GSD IV is challenging due to non-specific symptoms, such as liver and spleen enlargement, which can overlap with other hematologic and hepatobiliary disorders.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Rheumatology and Immunology, the Second Affiliated Hospital of Xiamen Medical College, Xiamen, China.
Introduction: Systemic lupus erythematosus (SLE) complicated by thrombotic microangiopathy (TMA) and non-cirrhotic portal hypertension (NCPH) is rare. We present a case of a female patient with SLE who developed TMA and NCPH and responded positively to rituximab and plasma exchange treatment.
Case Description: A 53-year-old woman was admitted with 6 h of confusion.
Clin Exp Immunol
January 2025
Department of Neurology, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China.
Introduction: Wound healing causes heavy economic burdens for families and society, becoming a critical issue in the global healthcare system. While the role of immune cells in the wound healing process is well-established, the involvement of B cells remains poorly understood. This study aims to elucidate the essentiality of B cells in wound repair.
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