Sera of 890 healthy Jinan residents were chosen randomly, and the concentrations of serum Zn and Cu were detected by atomic absorption spectrometry. The mean serum Zn and Cu concentrations and Zn/Cu were 1.32 +/- 0.49 mg/l, 0.99 +/- 0.26 mg/l, and 1.41 +/- 0.56, respectively. Significantly higher levels of serum Zn and Zn/Cu but lower serum Cu were found in the men. Descending tendency of serum Zn and Zn/Cu was observed with social-economic status and age but not significant. Alcohol consumption produced higher level of serum Zn and Zn/Cu but lower Cu concentration. Smoking caused significant lower level in serum Cu concentration but no significance in serum Zn and Zn/Cu. Serum Zn and Zn/Cu were normal only when hours of sleep a night were kept within 7-9 h. Higher level of serum Zn and Cu concentrations and Zn/Cu were observed in individuals with regular physical exercise, but still no significant difference existed. No clear relationship between educational levels with serum Zn and Cu concentrations and Zn/Cu was observed.
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http://dx.doi.org/10.1007/s12011-009-8350-9 | DOI Listing |
Autism Res
December 2024
School of Public Health, Hubei University of Medicine, Shiyan, China.
Imbalances in several trace elements related to antioxidant function may lead to autism spectrum disorder (ASD)-related physiological dysfunction. Nonetheless, contradictory results have been found on the connection between these elements and ASD, and studies of their joint effects and interactions have been insufficient. We therefore designed a case-control study of 152 ASD children and 152 age- and sex-matched typically developing (TD) children to explore the individual and combined associations of manganese (Mn), zinc (Zn), copper (Cu), and selenium (Se) with ASD.
View Article and Find Full Text PDFBiometals
December 2024
Department of Anesthesiology, Fukui Prefectural Hospital, 2-8-1 Yotsui, Fukui, 910-8526, Fukui, Japan.
Biol Trace Elem Res
August 2024
PG Department of Zoology, Sri Guru Gobind Singh College, Chandigarh, UT, India.
Various clinical manifestations associated with measurable abnormalities of Zn and Cu in serum and tissue were determined in Cancer-Patients (CP), and therefore, these two metals are drawing more and more attention presently than ever before. Cancer is a disease of uncontrolled-abnormal-cell-division with invasion-potential which was exhibited to occur due to dys-regulation/dys-homeostasis of fundamental-biological-pathways (FBP) including antioxidant-enzyme-defense-system, anti-inflammatory and immune-systems, and DNA-damage-repair-system in the human-body resulting in generation of chronic-oxidative-stress induced DNA-damage and gene-mutations, inflammation and compromised immune-system, tumor-induced increased angiogenesis, and inhibition of apoptosis processes. Zn and Cu were recognized to be the most crucial components of FBP and imbalance in Zn/Cu ratios in CP asserted to generate chronic toxicity in human body through various mechanisms including increased chronic oxidative stress linked compromised DNA integrity and gene mutations due to malfunctioning of DNA damage repair enzymes; increased angiogenesis process due to Zn- and Cu-binding proteins metallothionein and ceruloplasmin-induced enhanced expression of tumor growth factors; and elevation in inflammatory response which was further shown to down/upregulate gene expression of multiple Zn transporter proteins leading to dys-homeostasis of intracellular Zn concentrations, and it was determined to disturb the equilibrium between cell growth and division, proliferation, differentiation, and apoptosis processes which lead to cancer progression.
View Article and Find Full Text PDFBMC Pediatr
August 2024
Department of Pediatrics, Ali Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran.
Background: Drug-resistant epilepsy is defined as failure of seizure control in spite of using 2 or 3 proper antiepileptic drugs in appropriate time. Mineral elements play important roles in neuronal function; it is believed that mineral deficiency may lead to complications through seizure management. In the present study, serum levels of zinc (Zn), copper (Cu), magnesium (Mg), calcium (Ca), and 25-hydroxy vitamin D (Vit D) in drug-resistant-epilepsy (DRE) patients were evaluated and compared with the controlled patients.
View Article and Find Full Text PDFJ Cosmet Dermatol
December 2024
Department of Biochemistry, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
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