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Effect of Ketorolac Administration on the Rate of Nonunion of Operatively Treated Pediatric Long-Bone Fractures: A Matched Cohort Analysis.
J Bone Joint Surg Am
November 2024
Department of Orthopaedics, Washington University School of Medicine, St. Louis, Missouri.
Background: Nonunion is a rare yet serious complication in pediatric fracture healing that can lead to patient morbidity and economic burden. The administration of nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with an increased risk of fracture nonunion in adults, but data are lacking in the pediatric population. This study examines the relationship between postoperative ketorolac administration and nonunion in operatively managed pediatric long-bone fractures.
View Article and Find Full Text PDFRole of hypercoagulability in multifocal osteonecrosis.
BMJ Case Rep
December 2024
Sports Injury Division, Department of Trauma Surgery, All India Institute of Medical Sciences (AIIMS) Rishikesh, Rishikesh, India
Bone infarction describes bone marrow necrosis that occurs within a long bone's metaphysis or diaphysis. Multiple causative factors lead to ischaemia and subsequent necrosis of bone marrow. The role of hypercoagulability in bone ischaemia is a well-established phenomenon.
View Article and Find Full Text PDFExtensive humerus and scapula hydatidosis: A unique case report and comprehensive review of management strategies.
Int J Surg Case Rep
December 2024
Joint Reconstruction Research Center, Department of Orthopedics, Tehran University of Medical Sciences, Iran. Electronic address: https://twitter.com/Saeed_Khabiri.
Introduction And Importance: Bone hydatidosis is a rare manifestation of Echinococcus infection, presenting significant diagnostic and therapeutic challenges. This case report describes the successful management of an extensive hydatid disease involving the entire humerus and scapula.
Case Presentation: A 44-year-old male presented with progressive right arm pain and swelling.
Osteocytes contribute to sex-specific differences in osteoarthritic pain.
Front Endocrinol (Lausanne)
November 2024
Biomechanics and Bioengineering Research Centre Versus Arthritis, School of Biosciences, Cardiff University, Cardiff, United Kingdom.
Osteoarthritic (OA) pain affects 18% of females and 9.6% of males aged over 60 worldwide, with 62% of all OA patients being women. The molecular drivers of sex-based differences in OA are unknown.
View Article and Find Full Text PDFA Short Course of Preoperative Denosumab Injection Followed by Surgery in High-Risk Giant Cell Tumors of the Extremities: A Retrospective Study.
Indian J Surg Oncol
December 2024
Department of Pharmacology, All India Institute of Medical Sciences, Bhubaneswar, India.
Despite early promising results with denosumab treatment in giant cell tumor of bone (GCTB), recent studies have raised concerns about a high local recurrence rate following preoperative denosumab administration and joint preservation surgery. This retrospective study evaluated data from 25 high-risk GCT patients (Campanacci grade II or III with features like soft tissue extension, pathological fracture, minimal periarticular or subarticular bone) treated with five doses of neoadjuvant denosumab injection followed by either curettage and cementing ( = 13) or joint reconstruction with fibular graft/endoprosthesis ( = 12) between 2014 and 2019. With an average follow-up of 40 months, the study found only one patient of local recurrence.
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