Aims: Oxidative stress has recently been implicated in atrial fibrillation (AF); however, the mechanisms remain unclear. Herein, we hypothesize that probucol can attenuate atrial structure remodeling.
Methods: Twenty dogs were randomly divided into sham-operated, control, and probucol-treated groups. We identified apoptosis and histopathological changes in the atria. Oxidative stress was measured by lipid peroxidation and echocardiographic examinations were performed.
Results: Atrial apoptosis indexes were dramatically decreased in the probucol-treated group compared to the control group. Relative to the control group, the percentage of myolysis was dramatically decreased in the probucol-treated group (p < 0.01). There was less lipid peroxidation in the probucol-treated group than the control group. Atrial function was dramatically elevated in the probucol-treated group.
Conclusions: The results of this study indicate that the antioxidant probucol suppresses atrial structural remodeling and may act as a new therapy for AF.
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Probucol improves erectile function via Activation of Nrf2 and coordinates the HO-1 / DDAH / PPAR-γ/ eNOS pathways in streptozotocin-induced diabetic rats.
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Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People's Republic of China. Electronic address:
Background: Diabetic erectile dysfunction (DMED) is mainly attributed to oxidative stress, and Nrf2 plays an important role in cellular antioxidation and regulates NO production in the vascular endothelium. Probucol maintains endothelial function through its antioxidant activity. This study investigated the efficacy and mechanism of probucol in improving erectile function in streptozotocin-induced diabetic rats.
View Article and Find Full Text PDFProbucol Reduces Testicular Torsion/Detorsion-Induced Ischemia/Reperfusion Injury in Rats.
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Department of Surgery, First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province 310006, China.
This study investigated the effect of probucol, a potent antioxidant, on testicular torsion/detorsion-induced ischemia/reperfusion injury attributable to excess reactive oxygen species released by neutrophils. Sixty male Sprague-Dawley rats were randomly divided into sham-operated control, ischemia-reperfusion, and probucol-treated groups. In the ischemia-reperfusion group, testicular detorsion was performed after 2 hours of left testicular torsion.
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Oncotarget
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Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
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View Article and Find Full Text PDFProbucol Improves Erectile Function by Restoring Endothelial Function and Preventing Cavernous Fibrosis in Streptozotocin-induced Diabetic Rats.
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Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China. Electronic address:
Objective: To investigate the effects of probucol on erectile function in streptozotocin-induced diabetic rats and explore the underlying mechanisms.
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Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, 266071, China.
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