AI Article Synopsis
- Short and efficient methods for synthesizing both (+/-)-7-methylomuralide and (-)-7-methylomuralide have been created.
- Three successive tandem reactions are used to build the required carbon structure and stereochemistry of the target molecule, making the synthesis process much simpler.
- A chiral directing group is utilized to manage the stereochemistry in a crucial aldol reaction step.
Article Abstract
Short, practical, and scalable syntheses of (+/-)-7-methylomuralide and (-)-7-methylomuralide have been developed. Three consecutive tandem reaction pairs establish all of the carbons and the stereochemistry of the target molecule, vastly simplifying the synthetic scheme from N-trichloroethoxycarbonyl glycine. The chiral directing group controls the absolute stereochemistry of the key aldol reaction.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714661 | PMC |
| http://dx.doi.org/10.1021/ja901400q | DOI Listing |
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