AI Article Synopsis
- HPV infection is linked to some oral squamous cell carcinoma (OSCC) cases, which are becoming more common, and the role of HPV in cancer progression is still unclear.
- Researchers examined tissue samples from both HPV-positive and HPV-negative OSCC patients to identify relevant proteins associated with HPV.
- They found 18 proteins that differed between the two groups, including thioredoxin and epidermal-fatty acid binding protein, suggesting these proteins may be involved in the cancer's development related to HPV infection.
Article Abstract
Human papillomavirus (HPV) infection has been identified as an etiologic agent for a subset of oral squamous cell carcinoma (OSCC) with increasing incidence. HPV DNA-positivity may confer better prognosis but the related oncogenic mechanisms are unknown. For the identification of HPV relevant proteins, we analyzed microdissected cells from HPV DNA-positive (n = 17) and HPV DNA-negative (n = 7) OSCC tissue samples. We identified 18 proteins from tumor tissues by peptide fingerprint mapping and SELDI MS that were separated using 2-DE. Among a number of signals that were detected as significantly different in the protein profiling analysis, we identified thioredoxin (TRX) and epidermal-fatty acid binding protein as upregulated in HPV related tumor tissue. This study, investigating for the first time proteomic changes in microdissected HPV infected tumor tissue, provides an indication on the oncogenic potential of viruses.
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| http://dx.doi.org/10.1002/pmic.200800882 | DOI Listing |
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