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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Is Associated with HLA-A*3303 and HLA-DPB1*0501.
Ann Neurol
May 2024
Department of Genetics and Prenatal Diagnosis, Hainan Women and Children's Medical Center, Haikou, Hainan, China.
We determined the genetic association between specific human leucocyte antigen (HLA) loci and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Our results showed that autoimmune GFAP astrocytopathy was associated with HLA-A*3303 (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.
View Article and Find Full Text PDFHLA genotypes and cold medicine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis.
Sci Rep
June 2020
Center of Excellence for Environmental Health and Toxicology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand.
Serious cutaneous adverse drug reactions [i.e., SJS/TEN with severe ocular complications (SOC)] associated with cold medicine (CM) were reported in several studies.
View Article and Find Full Text PDFHLA-matched platelet transfusions are effective only in refractory patients with positive HLA antibody screening.
Transfusion
November 2019
Unit Transfusion Medicine, Sanquin Blood Bank, Amsterdam, The Netherlands.
Background: Recipients of platelet transfusions with 1-hour corrected count increments (1hCCIs) of 7.5 or less on two subsequent platelet transfusions with random platelets may benefit from human leukocyte antigen (HLA)-matched platelet concentrates. We aimed to quantify the efficacy of HLA-matched platelets concentrates expressed in 1hCCIs.
View Article and Find Full Text PDF[Relationship between HLA Gene Polymorphism and Aplastic Anemia in Northern Chinese Han Patients].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2018
Department of Hematology, First Affiliated Hospital, Chinese PLA General Hospital, Beijing 100048,
Article Synopsis
- The study investigates how specific genetic variations (polymorphisms) in certain HLA genes are linked to the occurrence of aplastic anemia (AA) in 65 patients from Northern China.
- Researchers used advanced genetic testing methods on both AA patients and a larger group of healthy controls to compare allele frequencies, finding significant associations between specific HLA genes and AA.
- Key findings indicate that certain alleles like HLA-B*1302 and HLA-DRB1*0901 are more common in AA patients, suggesting they may increase susceptibility to the condition, while HLA-A*3303 and HLA-DQB1*0302 appear to have a protective effect.
Association between HLA alleles and lamotrigine-induced cutaneous adverse drug reactions in Asian populations: A meta-analysis.
Seizure
August 2018
Department of Neurology, West China Hospital of Sichuan University Chengdu, Sichuan 610041, China. Electronic address:
Purpose: The aim of this study was to assess the association between human leukocyte antigen (HLA) variants and lamotrigine (LTG)-induced cutaneous adverse drug reactions (cARDs).
Methods: A comprehensive literature search was conducted on the relationship of HLA alleles with LTG-induced cADRs in Asian populations, through PubMed, Embase, and Cochrane Library. The last search was in February 2018.
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