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A case of karyomegalic interstitial nephritis without FAN1 mutations in the setting of brentuximab, ifosfamide, and carboplatin exposure.
BMC Nephrol
November 2024
Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Background: Karyomegalic interstitial nephritis (KIN) is a rare renal diagnosis associated with both genetic and medication etiologies. The primary gene associated with KIN is the FAN1 gene which encodes a protein responsible for DNA interstrand repair. Common medication triggers of KIN are chemotherapeutic agents, especially those which disrupt DNA structure such as carboplatin.
View Article and Find Full Text PDFBrentuximab-Induced Colitis in a Non-Stem-Cell Transplant Patient.
ACG Case Rep J
January 2023
Department of Gastroenterology, Advocate Lutheran General Hospital, Park Ridge, IL.
Many chemotherapeutic agents have been associated with drug-induced colitis (DIC). With newer agents' expansion of approval as first-line therapy for common cancers, it is important to be cognizant of their association with DIC. We present a case of brentuximab-associated DIC in an elderly woman with CD30+ Hodgkin lymphoma.
View Article and Find Full Text PDFDrug-induced cutaneous pseudolymphoma: A systematic review of the literature.
Australas J Dermatol
February 2023
Department of Dermatology, Razi Hospital, Tehran University of medical sciences, Tehran, Iran.
Article Synopsis
- Drug-induced cutaneous pseudolymphoma (CPL) is a skin condition linked to various medications, and a systematic review identified the most common drugs causing it.
- The study analyzed 56 articles involving 89 reported cases, focusing on patient demographics, clinical features, and histopathological findings; the average age of patients was about 54 years, with a noticeable occurrence of symptoms usually 120 days after drug intake.
- The primary drug categories associated with CPL are anti-hypertensives, anticonvulsants, monoclonal antibodies, and antidepressants, with phenytoin being the most frequently reported specific drug.
Increased CD30 cells in skin lesions of drug-induced hypersensitivity syndrome: Are type-2 innate lymphoid cells present?
J Dermatol
September 2021
Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
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