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A new twist on superantigen-activated autoimmune disease.
J Clin Invest
January 2025
Division of Rheumatology, Center of Excellence for Intestinal and Immunology Research, University of Alberta, Edmonton, Alberta, Canada.
Superantigen-induced (Sag-induced) autoimmunity has been proposed as a mechanism for many human disorders, without a clear understanding of the potential triggers. In this issue of the JCI, McCarthy and colleagues used the SKG mouse model of rheumatoid arthritis to characterize the role of Sag activity in inflammatory arthritis by profiling arthritogenic naive CD4+ T cells. Within the diseased joints, they found a marked enrichment of T cell receptor-variable β (TCR-Vβ) subsets that were reactive to the endogenously encoded mouse mammary tumor virus (MMTV) Sag.
View Article and Find Full Text PDFC9orf72 role in myeloid cells: new perspectives in the investigation of the neuro-immune crosstalk in amyotrophic lateral sclerosis and frontotemporal dementia.
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Department of Neuroscience, Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Jefferson Hospital for Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA.
Curcumin in gastric cancer treatment: A commentary on mechanistic insights and future directions.
World J Gastrointest Oncol
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Department of Special Service, No. 988 Hospital of the Joint Service Support Force of PLA, Zhengzhou 450042, Henan Province, China.
The study by Yang presents a comprehensive investigation into the therapeutic potential of curcumin for gastric cancer (GC). Using network pharmacology, the researchers identified 48 curcumin-related genes, 31 of which overlap with GC targets. Key genes, including , , , , , and , are linked to poor survival in GC patients.
View Article and Find Full Text PDFTransforming hyperthermic intraperitoneal chemotherapy: using computer simulation to improve HIPEC treatments.
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Department of Anesthesiology, Pain Management & Perioperative Medicine, Henry Ford Health, Detroit, MI, USA.
A light in the dark.
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Department of Pediatrics, Section of Pediatric Emergency Medicine, Yale School of Medicine, Connecticut, USA.
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