AI Article Synopsis
- Actinic Prurigo (AP) is a skin condition that causes chronic itching, primarily affecting certain ethnic groups with specific genetic markers, but the role of dendritic cells in the skin has not been previously studied.
- The study aimed to examine the status of Langerhans Cells (LC), a type of dendritic cell, in the skin of AP patients by comparing affected and unaffected areas.
- Results showed a significant decrease in the number of Langerhans Cells in the lesional skin compared to non-lesional skin, indicating a possible link between LC frequency and the condition.
Article Abstract
Background: Actinic Prurigo (AP) is a chronic pruritic dermatosis of unknown cause affecting sun exposed skin in defined ethnic groups with characteristic MHC alleles. However, the cutaneous dendritic cells have not been assessed.
Objective: To assess in situ the epidermal Langerhans Cell (LC) status in Actinic Prurigo.
Study Design: Fresh skin samples from three AP patients were used to evaluate in situ the epidermal LC, comparing lesional and non-lesional sites in each subject.
Setting: AP patients attending the Dermatology Department at the Hospital M. Gea-Gonzalez in Mexico city.
Methods: Lesional and non-lesional skin samples were taken from each subject to prepare both epidermal sheets and conventional tissue sections. Three markers restricted to LC in epidermis (CD1a, ATPase, MHC-II) were used to quantify the LC per area in epidermal sheets.
Results: Compared to non-lesional skin from the same subject, a significant reduction in the number of LC per area of epidermis was found in lesional skin; with any of the three markers evaluated.
Conclusion: The frequency of epidermal LC decreases importantly in lesional skin from AP patients.
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| http://dx.doi.org/10.1111/j.1468-3083.2008.03060.x | DOI Listing |
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