Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase expressed abundantly in the heart. CaMKII targets numerous proteins involved in excitation-contraction coupling and excitability, and its activation may simultaneously contribute to heart failure and cardiac arrhythmias. In this review, we summarize the modulatory effects of CaMKII on cardiac ion channel function and expression and illustrate potential implications in the onset of arrhythmias via a computer model.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784004 | PMC |
| http://dx.doi.org/10.1097/FJC.0b013e3181a25078 | DOI Listing |
Publication Analysis
Top Keywords
calcium/calmodulin-dependent kinase
8
cardiac ion
8
kinase regulation
4
regulation cardiac
4
ion channels
4
channels calcium/calmodulin-dependent
4
kinase camkii
4
camkii multifunctional
4
multifunctional serine/threonine
4
serine/threonine kinase
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!