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| http://dx.doi.org/10.1148/radiol.2511080671 | DOI Listing |
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INWORKS and Hiroshima/Nagasaki Leukaemia Results.
Dose Response
December 2024
Canadian Nuclear Laboratories - Retired, Chalk River, ON, Canada.
The Hiroshima/Nagasaki (H/N) studies by the Radiation Effect Research Foundation have not shown increased leukaemia for acute doses below 200 milli-gray (mGy). By contrast the INWORKS study of leukaemia in workers stated: "This study provides strong evidence of positive associations between protracted low-dose radiation exposure and leukemia". The INWORKS study also claimed increased leukaemia, not including Chronic Lymphocytic Leukaemia, at cumulative occupational doses of less than 100 mGy.
View Article and Find Full Text PDFThink Beyond the Room: Measuring Relative Humidity in the Home Cage and Its Impact on Reproduction in Laboratory Mice, .
Animals (Basel)
November 2024
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Relative humidity (RH) is measured in vivaria with a broad range to accommodate seasonal fluctuations. It is assumed that measurements in the room (macroenvironment) reflect those in the cage (microenvironment). However, there is limited data comparing RH in the macroenvironment to the microenvironment and how the mice may be affected by variations in RH that fall within husbandry recommendations.
View Article and Find Full Text PDFRandom Threshold Model: A Low-Dose Radiation-Induced Risk Assessment Approach Considering Individual Susceptibility to Cancer.
Dose Response
November 2024
Department of Biomedical Science and Technology, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
The linear no-threshold (LNT) model, which has been used for radiation protection purposes, was developed based on the assumption that exposure to even a small amount of radiation may cause cancer. However, although it is known in carcinogenesis that there is variation in radiation sensitivity among individuals, the LNT model does not adequately consider radiosensitive subgroups. In this paper, we represent susceptibility to contract cancer by radiation exposure by means of the threshold of a dose-response function, introduce an assumption that the thresholds are random to represent the variation of the radiosensitivity among individuals in a susceptible subgroup.
View Article and Find Full Text PDFRadiation adaptive response for constant dose-rate irradiation in high background radiation areas.
Radiat Environ Biophys
October 2024
Faculty of Physics, Warsaw University of Technology, ul. Koszykowa 75, Warszawa, 00-662, Poland.
The presented paper describes the problem of human health in regions with high level of natural ionizing radiation in various places in the world. The radiation adaptive response biophysical model was presented and calibrated for the special case of constant dose-rate irradiation. The calibration was performed for the data of residents of several high background radiation areas, like Ramsar in Iran, Kerala in India or Yangjiang in China.
View Article and Find Full Text PDFCardiac radiation exposure and incident cancer: challenges and opportunities.
Eur Heart J Cardiovasc Imaging
November 2024
CORRIB Research Centre for Advanced Imaging and Core Laboratory, University of Galway, Galway, Ireland.
The use of radiological procedures has enormously advanced cardiology. People with heart disease are exposed to ionizing radiation. Exposure to ionizing radiation increases lifetime cancer risk with a dose-proportional hazard according to the linear no-threshold model adopted for radioprotection purposes.
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