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http://dx.doi.org/10.1503/cmaj.070109 | DOI Listing |
Cureus
November 2024
Department of Pain Medicine, Fondazione Paolo Procacci, Rome, ITA.
The present investigation evaluated transcutaneous electrical nerve stimulation (TENS) for the non-pharmacological treatment of post-herpetic neuralgia (PHN). PHN is the most common complication of the Herpes Zoster virus, affecting one in every five patients with shingles, and presents as intense neuropathic pain that can persist for 90 days or longer after the initial onset of symptoms. Current pharmacological treatment options are mainly limited to symptom management, including oral medications such as tricyclic antidepressants and gabapentinoid preparations, as well as topical options such as lidocaine or capsaicin.
View Article and Find Full Text PDFCureus
November 2024
Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA.
Hypercalcemia is a common metabolic complication associated with malignancies, particularly in solid tumors, such as lung and breast cancers. However, its occurrence in hematologic malignancies, including diffuse large B-cell lymphoma (DLBCL), is rare. The pathophysiology of hypercalcemia in lymphomas is often related to the secretion of parathyroid hormone (PTH)-related peptide (PTHrP).
View Article and Find Full Text PDFKorean J Fam Med
November 2024
Department of Family Medicine, Wayne State University School of Medicine, Rochester, MI, USA.
Long coronavirus disease (COVID), also known as the post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC), is a significant concern since the end of the COVID-19 pandemic, as it still manifests in individuals with persistent symptoms and complications beyond the acute phase of infection. Defining this disease is challenging, as it manifests as a spectrum of symptoms varying in severity among individuals who have previously tested positive for COVID-19. Long COVID is more prevalent in hospitalized COVID-19 patients and presents in various ways, ranging from pulmonary to extrapulmonary symptoms.
View Article and Find Full Text PDFMed Sci (Basel)
November 2024
Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
Background: The use of beta-blockers in the perioperative period has been widely investigated due to their potential to reduce the risk of major adverse cardiovascular and cerebrovascular events (MACCE) and mortality; yet their overall impact on various postoperative outcomes remains debated. This study constitutes a systematic review and meta-analysis of the impact of beta-blockers on mortality, MI, stroke, and other adverse effects such as hypotension and bradycardia in patients undergoing non-cardiac surgery.
Methods: A comprehensive systematic review and meta-analysis were conducted according to PRISMA 2020 guidelines.
Cureus
October 2024
Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA.
Cardiovascular diseases (CVDs) are the major cause of mortality worldwide, emphasizing the critical need for timely and accurate diagnosis. Artificial intelligence (AI) and machine learning (ML) have become revolutionary tools in the healthcare system with significant potential for cardiovascular diagnosis and imaging. AI and ML techniques, including supervised and unsupervised learning, logistic regression, deep learning models, neural networks, and convolutional neural networks (CNNs), have significantly advanced cardiovascular imaging.
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