AI Article Synopsis
- The study aimed to assess the prevalence of celiac disease in patients with systemic sclerosis (SSc), noting a lack of research on this specific autoimmune disease combination.
- Researchers tested 50 SSc patients for specific antibodies (anti-tTG and anti-EMA) while they continued a gluten diet, confirming celiac disease through biopsies in some cases.
- The findings indicated that 8% of SSc patients had celiac disease, with 5 positives for anti-tTG antibodies, and 4 confirmed through histology, suggesting a higher prevalence of celiac disease in the SSc population.
Article Abstract
Objective: To evaluate the presence of celiac disease in patients with systemic sclerosis (SSc). The association of autoimmune diseases with celiac disease has been reported, but few publications deal with the combination of SSc and celiac disease.
Methods: We investigated the presence of anti-tissue transglutaminase (anti-tTG) antibodies and serum antiendomysial antibodies (anti-EMA) in 50 patients with SSc. All subjects were on a gluten-containing diet. Duodenal mucosa histology and biopsy culture were performed in anti-tTG-positive patients; anti-EMA and IgA, IgG1 anti-tTG were detected in culture supernatants.
Results: The incidence of celiac disease in patients with SSc was found to be 8%. Serum anti-tTG antibody-positive results were detectable in 5 out of 50 patients with SSc, but only in 4 of them was the diagnosis confirmed by histological results (Marsh classification).
Conclusion: Our data show an increased prevalence of celiac disease in patients with SSc.
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| http://dx.doi.org/10.3899/jrheum.081000 | DOI Listing |
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