AI Article Synopsis

  • A new pharmacophore was designed combining features of THC and anandamide to create stable, potent cannabinoid receptor ligands.
  • The study involved synthesizing and analyzing resorcinol-anandamide hybrids, focusing on varying side chains.
  • Results showed that certain compounds, particularly those with a 2-methyloctan-2-yl group and specific alkyloxy chains, had high affinity for CB receptors and promising antinociceptive effects.

Article Abstract

Bearing in mind the pharmacophoric requirements of both (-)-trans-Delta(9)-tetrahydrocannabinol (THC) and anandamide (AEA), we designed a novel pharmacophore consisting of both a rigid aromatic backbone and a flexible chain with the aim to develop a series of stable and potent ligands of cannabinoid receptors. In this paper we report the synthesis, docking studies, and structure-activity relationships of new resorcinol-anandamide "hybrids" differing in the side chain group. Compounds bearing a 2-methyloctan-2-yl group at position 5 showed a significantly higher affinity for cannabinoid (CB) receptors, in particular when an alkyloxy chain of 7 or 10 carbon atoms was also present at position 1. Derivative 32 was a potent CB(1) and CB(2) ligand, with K(i) values similar to that of WIN 55-212 and potent antinociceptive activity in vivo. Moreover, derivative 38, although less potent, proved to be the most selective ligand for CB(2) receptor (K(i)(CB(1)) = 1 muM, K(i)(CB(2)) = 35 nM).

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http://dx.doi.org/10.1021/jm8016255DOI Listing

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Article Synopsis
  • A new pharmacophore was designed combining features of THC and anandamide to create stable, potent cannabinoid receptor ligands.
  • The study involved synthesizing and analyzing resorcinol-anandamide hybrids, focusing on varying side chains.
  • Results showed that certain compounds, particularly those with a 2-methyloctan-2-yl group and specific alkyloxy chains, had high affinity for CB receptors and promising antinociceptive effects.
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