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The E3 ubiquitin ligase MARCH1 mediates downregulation of plasma membrane GABA receptors under ischemic conditions by inhibiting fast receptor recycling.
Sci Rep
January 2025
Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
GABA receptors mediate prolonged inhibition in the brain and are important for keeping neuronal excitation and inhibition in a healthy balance. However, under excitotoxic/ischemic conditions, GABA receptors are downregulated by dysregulated endocytic trafficking and can no longer counteract the severely enhanced excitation, eventually triggering neuronal death. Recently, we developed interfering peptides targeting protein-protein interactions involved in downregulating the receptors.
View Article and Find Full Text PDFEnergy, Aromatic, and Medicinal Plants' Potential and Prospects for the Remediation of Potentially Toxic Element-Contaminated Agricultural Soils: A Critical Meta-Analysis.
Toxics
December 2024
Soil Science Laboratory, School of Agriculture, Faculty of Agriculture, Forestry and Natural Environment, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
A critical meta-analysis of the past decade's investigations was carried out with the aim of assessing the use of plant-based techniques for soil remediation. Potentially toxic element (PTE) contaminated soils were selected since these contaminants are considered hazardous and have long-term effects. Furthermore, energy, aromatic, and medicinal plants were studied as their high-value products seem to be affected by PTEs' existence.
View Article and Find Full Text PDFPromising Probiotic Candidates for Sustainable Aquaculture: An Updated Review.
Animals (Basel)
December 2024
Faculty of Bioscience, Fisheries and Economics, Norwegian College of Fishery Science, UiT The Arctic University of Norway, 9019 Tromsø, Norway.
With the intensification of aquaculture to meet the rising demands of fish and shellfish, disease outbreaks during the larval and adult stages are a major challenge faced by aqua culturists. As the prophylactic use of vaccines and antibiotics has several limitations, research is now focused on sustainable alternatives to vaccines and antibiotics, e.g.
View Article and Find Full Text PDFFracture Resistance and Wear Behavior of Ultra-Thin Occlusal Veneers Made From Translucent Zirconia Ceramics Bonded to Different Tooth Substrates.
J Esthet Restor Dent
January 2025
Department of Prosthodontics, Propaedeutics and Dental Materials, School of Dentistry, Christian-Albrechts University at Kiel, Kiel, Germany.
Objective: Investigation of the mechanical properties of occlusal veneers made from zirconia with varying translucency, bonded to different tooth substrates.
Materials And Methods: Sixty-four extracted molars were divided into two groups: preparation within enamel (E) or extending into dentin (D). Veneers were milled from four zirconia ceramics (n = 8): 5Y-TZP (HT), a multilayer of 5 and 3Y-TZP (GT), 3Y-TZP (LT), and 4Y-TZP (MT).
In Web We Trust: The Promised Cannabidiol Effects on Obesity as a Matter of Language and Marketing on Webpages.
Curr Neuropharmacol
January 2025
Department of Health Sciences, University of Catanzaro 'Magna Græcia', Viale Europa, 88100 Catanzaro, Italy.
Background: Today more and more people search the web for health-related information, risking to come across misinformation and biased content that may affect their treatment decisions. Cannabidiol (CBD) is among the products for which beneficial effects have been claimed, often at the expense of the risks; further keeping in mind unreliable information reported on products themselves.
Objective: This study evaluated the quality of information retrieved by Google on the potential effects of CBD on weight management, also comparing Italian and English contents, hypothesizing generally low quality and language-driven differences in offered information.
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