This is the first report documenting the presence of a high number of Cyniclomyces guttulatus yeasts in the faeces of a cat. The animal was initially presented with acute complaints of vomiting and diarrhoea. The patient responded well to oral salazosul-fapyridine but the stools remained soft and C. guttulatus yeasts were still present. After a course of nystatin (15,000 IU/kg bw q24 PO for 4 days) the stools were normal and no yeasts were found anymore (centrifugation/flotation/zinc sulphate). C. guttulatus occurs naturally in the digestive tract of rabbits, guinea pigs, chinchillas, rats and mice. It is occasionally found in massive numbers in the faeces of dogs with diarrhoea; part of these patients respond well to nystatin treatment. Recent experience indicates that the most effective dosage of nystatin for dogs and cats is 50.000 IU/kg q24 PO for 4 days.
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