Objective: To evaluate the effect of intravaginally misoprostol at start dosages of 25 microg and 50 microg when used for pre-induction cervical ripening among nulliparous parturients.
Methods: Our observational study involves all cases of partus induction consecutively registered in a Norwegian hospital between September 2002 and August 2006, with the following inclusion criteria: nulliparous, singleton pregnancies >or=37 weeks, an unfavourable cervix (Bishop score
Results: Vaginal delivery within 48 h after the initial dose occurred more often in the 25 microg-group than in the 50 microg-group (75 vs. 58%, p = 0.018). The rate of caesarean section was lower in the 25 microg-group than in the 50 microg-group (19 vs. 33%, p = 0.043). These differences remained significant after adjusting for confounders.
Conclusion: Our findings support the notion that the dose of 25 microg misoprostol is as at least as efficient as 50 microg in nulliparous parturients.
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