AI Article Synopsis
- The study investigated the effects of Hippophae rhamnoides L. extract (HRe-1) and dexpanthenol on blood flow in wound areas of rats.
- Burn wounds were created on rats, and the treatments were applied to one thigh for 8 days, with blood flow measured using the (133)Xe clearance technique.
- Results showed that HRe-1 significantly increased blood flow in the wound region compared to dexpanthenol, suggesting HRe-1 is more effective for skin wound healing.
Article Abstract
Unlabelled: The aim of the present experimental study was to determine and compare the effect of Hippophae rhamnoides L. extract (HRe-1) and of dexpanthenol on the blood flow of a wound region, in rats using xenon-133 ((133)Xe) clearance technique.
Methods: Burn wounds were made on both thighs of rats and, HRe-1 and dexpanthenol were applied topically on the wound region only in the right thigh for a period of 8 days. The effect of HRe-1 and of dexpanthenol on blood flow of the wound region was assessed before and after their topical application by using the (133)Xe clearance technique.
Results: HRe-1 increased significantly blood flow of the wound region (P<0.05). Dexpanthenol showed a smaller increase in blood flow. In conclusion, our results in rats suggest that HRe-1 increases blood flow of the wound area and can be used for the treatment of skin wound healing, preferably than dexpanthenol.
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