Otolaryngol Head Neck Surg
Department of Otolaryngology, Head & Neck Surgery, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Published: April 2009
Objective: The purpose of this study was to investigate the effects of environmental tobacco smoke (ETS) and house dust mite allergen (HDMA) on the laryngeal mucosa of guinea pigs.
Study Design: Prospective, controlled animal study.
Subjects And Methods: Sixteen juvenile guinea pigs were randomly assigned to one of four treatment groups: (1) filtered air, (2) HDMA, (3) ETS, and (4) ETS and HDMA. The mucosal response of retrieved larynges was measured by eosinophil grade and stored mucin index.
Results: HDMA exposure increased eosinophil grade in the supraglottis. The mean eosinophil grade in the supraglottis was 1.25 (+/-1.26) in the filtered air group. The grade increased to 3.60 (+/-0.89) in the HDMA group (P = 0.021) and 3.00 (+/-1.16) in the ETS/HDMA group (P = 0.078). HDMA and ETS exposure was associated with increased mucin index in the subglottis. The grade increased from 1.50 (+/-1.73) in the control group to 3.25 (+/-0.50) in the ETS, 2.80 (+/-1.64) in the HDMA, and 3.25 (+/-0.50) in the ETS/HDMA group (P < 0.05).
Conclusion: Exposure to HDMA was associated with eosinophilia in the supraglottis. Exposure to HDMA and ETS was associated with elevated mucin in the subglottis. These results provide further evidence that ETS and inhaled allergens may play a role in the development of chronic laryngitis.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.otohns.2008.12.034 | DOI Listing |
World Allergy Organ J
November 2019
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
CLCA1 is a member of the CLCA (calcium-activated chloride channel regulator) family and plays an essential role in goblet cell mucus production from the respiratory tract epithelium. CLCA1 also regulates Ca-dependent Cl transport that involves the channel protein transmembrane protein 16A (TMEM16A) and its accessary molecules. CLCA1 modulates epithelial cell chloride current and participates in the pathogenesis of mucus hypersecretory-associated respiratory and gastrointestinal diseases, including asthma, chronic obstructive pulmonary disease, cystic fibrosis, pneumonia, colon colitis, cystic fibrosis intestinal mucous disease, ulcerative colitis, and gastrointestinal parasitic infection.
View Article and Find Full Text PDFClin Rev Allergy Immunol
August 2012
School of Veterinary Medicine, Department of Pathology, Microbiology, and Immunology, University of California, Davis, One Shields Avenue, 4206 VM3A, Davis, CA 95616-5270, USA.
The prevalence and severity of asthma is sexually dimorphic. Adult women have a higher incidence of asthma than men. This suggests that this disease may have a hormonal component.
View Article and Find Full Text PDFOtolaryngol Head Neck Surg
April 2009
Department of Otolaryngology, Head & Neck Surgery, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Objective: The purpose of this study was to investigate the effects of environmental tobacco smoke (ETS) and house dust mite allergen (HDMA) on the laryngeal mucosa of guinea pigs.
Study Design: Prospective, controlled animal study.
Subjects And Methods: Sixteen juvenile guinea pigs were randomly assigned to one of four treatment groups: (1) filtered air, (2) HDMA, (3) ETS, and (4) ETS and HDMA.
Clin Exp Allergy
February 2007
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Background: Asthma affects males and females differently. Females have a higher incidence than males after the onset of puberty. This suggests a hormonal component to the development of the disease.
View Article and Find Full Text PDFAm J Respir Crit Care Med
January 1996
Department of Pediatric Pulmonology, Beatrix Children's Hospital, The Netherlands.
The influence of exogenous factors in the home on the circadian variation of airway obstruction has not been fully assessed in children with asthma. The aim of the present study was to investigate the contribution of exogenous stimuli to the degree of peak expiratory flow (PEF) variability during 24 h. Fifty-five children (33 boys and 22 girls; mean age, 9.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.