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[Photoprotection and its implications for drug safety].
Med Pr
November 2024
Uniwersytet Jagielloński Collegium Medicum / Jagiellonian University Medical College, Kraków, Polska (Wydział Farmaceutyczny, Katedra Chemii Nieorganicznej i Analityki Farmaceutycznej / Faculty of Pharmacy, Department of Inorganic and Pharmaceutical Analytics).
Appropriate photoprotection plays a key role in the safety of using medicinal preparations whose active substances may induce photosensitivity reactions. This aspect applies not only to drugs applied topically to the skin, but also systemically. Drug-induced photosensitivity reactions to light depend on the active substance contained in the medicinal product and its dose, which translates into the concentration in the skin, the type of ultraviolet radiation, its intensity and exposure time.
View Article and Find Full Text PDFMUSTARDE ROTATION FLAP AS ADEQUATE OPTION FOR HIGH-RISK BCC NEAR THE LOWER EYE LID: THE ADDITIONAL INTAKE OF N-NITROSO-FOLIC-ACID AND N-NITROSO-RIVOROXABAN AS COFACTORS/TRIGGERS OF THE METABOLIC REPROGRAMMING OF THE FUTURE CANCER CELL.
Georgian Med News
June 2024
2Department of Dermatology and Venereology, Medical Institute of Ministry of Interior, Sofia, Bulgaria.
Article Synopsis
- The contamination of various drugs with nitrosamines, which are linked to skin cancer, is becoming a growing concern, particularly in relation to keratinocyte cancer and drug-induced carcinogenesis.
- Nitrosamines can have both phototoxic and genotoxic effects, and the possibility of drug-induced skin cancer is heightened when multiple contaminated drugs are taken simultaneously, potentially activating oncogenes and deactivating tumor suppressor genes.
- A case study highlights a female patient who developed three basal cell carcinomas after being treated with contaminated medications, suggesting that such contamination could significantly contribute to skin cancer risk in polypharmacy.
PERIOCULAR HIGH RISK BCCS AFTER ADDITIONAL/PARALLEL INTAKE OF TORASEMIDE, MOXONIDINE AND MIRABEGRON: IMPORTANT LINKS TO SKIN CANCER RELATED (PHOTO-) NITROSOGENESIS IN THE CONTEXT OF PHARMACO-ONCOGENESIS.
Georgian Med News
February 2024
3Department of Ophtalmology, Medical Instittute of Ministry of Interior, Sofia, Bulgaria.
The Nitrosogenesis of skin cancer is a modern newly introduced concept in medicine, mainly concerning melanoma, but also keratinocytic cancers such as basal cell carcinoma. The nitroso-contamination of more than 300 drugs worldwide and the permanent (relatively short-term) intake of mutagen-contaminated drugs could create serious prerequisites for the development of skin cancer. Retrospective but also prospective analyses following potentially contaminated polymedication with a heterogeneous type of nitrosamines in real patients are indicative of a causal connection rather than a sporadic association between 1) intake of a possibly nitrosamine-contaminated drug and 2) generation of keratinocytic skin cancer.
View Article and Find Full Text PDF[Current problems of polypharmacy in geriatric patients when taking drugs with a risk of photosensitivity.].
Adv Gerontol
March 2024
Scientific and Innovation Center «Professional Longevity», 11/16-78 Gavanskaya str., St. Petersburg 199106, Russian Federation, e-mail:
The article presents an overview of the current problems of polypharmacy in geriatric patients when taking drugs with a risk of photosensitivity. The article contains information about emerging adverse drug reactions, as well as methods for diagnosing, correcting and preventing phototoxic and photoallergic reactions in patients of older age groups. The main aspects of dermatological support in the system of long-term care for geriatric patients when taking drugs with a risk of photosensitivity are outlined.
View Article and Find Full Text PDFDrug-induced ultraviolet B photosensitivity due to hydroxychloroquine: The unexpected side effect.
Contact Dermatitis
February 2023
Department of Dermatology, Hospital del Mar- Institut Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona (UAB) and Universitat Pompeu Fabra (UPF), Barcelona, Spain.
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