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Clinical impact of inappropriate DOAC dosing in atrial fibrillation: Insights from a real-world registry.
Int J Cardiol Heart Vasc
February 2025
Department of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Germany.
Background: A significant number of patients with atrial fibrillation (AF) on direct oral anticoagulants (DOACs) receives off-label or inappropriate doses. This study examines the prevalence, dosages, and clinical outcomes in AF-patients on DOAC therapy admitted to an emergency department (ED).
Methods: This retrospective single-center observational study utilized data from the Heidelberg Registry of Atrial Fibrillation (HERA-FIB), consecutively including patients with AF presenting to the ED of the University Hospital of Heidelberg from June 2009 to March 2020.
Azole Antifungal Consumption in Community Pharmacy Sales in Mainland Portugal: Trend Analysis from 2014 to 2023.
Antibiotics (Basel)
January 2025
Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal.
: Excessive or inadequate use of antimicrobial drugs may lead to the emergence of resistant strains. For this reason, it is important to monitor consumption indicators to assess drugs' utilization over time. This study aimed to analyze the consumption of medically prescribed azole antifungal drugs in mainland Portugal from 2014 to 2023, focusing on those directed to genital infections: fluconazole, isoconazole, itraconazole, and sertaconazole.
View Article and Find Full Text PDFNephrotic and Non-Nephrotic Focal Segmental Glomerulosclerosis: Clinical Characteristics, Etiology, and Columbia Classification.
Diagnostics (Basel)
January 2025
Laboratory of Renal Pathophysiology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo 05508-220, Brazil.
: Focal segmental glomerulosclerosis (FSGS) is a pattern of kidney injury with diverse causes and pathogeneses, resulting in podocyte injury and depletion. It can be classified as primary, genetic, or secondary. Because FSGS classically has a worse prognosis in patients with nephrotic syndrome, most studies have focused on the treatment and evolution of these patients, resulting in a lack of data related to patients without nephrotic syndrome.
View Article and Find Full Text PDFSpatial-temporal evolution of the allometric relationship between urban economic and health resources in the Yangtze River Delta urban agglomeration.
PLoS One
January 2025
School of Pharmaceutical Economics and Management, Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China.
The evolution of the spatiotemporal relationship between urban economic growth and health resources within the Yangtze River Delta urban agglomeration provides an important context for understanding the regional development dynamics in China. Previous studies focused on equity in health-resource allocation and service efficiency, often overlooking the allometric growth relationships between health resources and economic variables. This study employs an allometric growth model to elucidate the changing interactions between the number of medical beds, doctors, and urban economic indicators in the Yangtze River Delta region from 2009 to 2022.
View Article and Find Full Text PDFThe persistence of very low correlations between NIH research funding and disease burdens.
Public Health Pract (Oxf)
June 2025
California State University Long Beach, Long Beach, CA, USA.
Objectives: The degree to which the allocation of disease-specific research funding by the NIH is proportional to disease burden is an important question. This study examined the historical relationship between NIH funding allocation and disease burden for a variety of medical conditions.
Study Design: Coefficients of relatedness for the linear relationships between funding and disease burden for 27 medical conditions over a period exceeding twenty years were calculated.
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