Gecko adhesion has become a paradigmatic example of bio-inspired engineering, yet among the many gecko-like synthetic adhesives (GSAs), truly gecko-like performance remains elusive. Many GSAs have previously demonstrated one or two features of the gecko adhesive. We present a new wedge-shaped GSA that exhibits several gecko-like properties simultaneously: directional features; zero force at detachment; high ratio of detachment force to preload force; non-adhesive default state; and the ability to maintain performance while sliding, even after thousands of cycles. Individual wedges independently detach and reattach during sliding, resulting in high levels of shear and normal adhesion during drag. This behaviour provides a non-catastrophic failure mechanism that is desirable for applications such as climbing robots where sudden contact failure would result in serious falls. The effects of scaling patch sizes up to tens of square centimetres are also presented and discussed. Patches of 1 cm(2) had an adhesive pressure of 5.1 kPa while simultaneously supporting 17.0 kPa of shear. After 30 000 attachment/detachment cycles, a patch retained 67 per cent of its initial adhesion and 76 per cent of its initial shear without cleaning. Square-based wedges of 20 mum and 50 mum are manufactured in a moulding process where moulds are fabricated using a dual-side, dual-angle lithography process on quartz wafers with SU-8 photoresist as the mould material and polydimethylsiloxane as the cast material.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817158PMC
http://dx.doi.org/10.1098/rsif.2009.0048DOI Listing

Publication Analysis

Top Keywords

cent initial
8
microfabricated wedge-shaped
4
wedge-shaped adhesive
4
adhesive array
4
array displaying
4
gecko-like
4
displaying gecko-like
4
gecko-like dynamic
4
adhesion
4
dynamic adhesion
4

Similar Publications

Background & objectives Cancer is a leading cause of death worldwide and constitutes a public health priority. Delays in diagnosis and treatment of cancer can adversely impact survival, recovery, and cost of treatment. The objective of this study was to estimate the proportion seeking timely care among those having early warning signals for oral, breast or cervical cancer and to explore the facilitators and barriers to early detection.

View Article and Find Full Text PDF

Disseminated tumor cells in bone marrow as predictive classifiers for small cell lung cancer patients.

J Natl Cancer Cent

December 2024

Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.

Article Synopsis
  • Small cell lung cancer (SCLC) is aggressive, with aneuploid circulating tumor cells (DTCs) and endothelial cells (DTECs) believed to drive metastasis, but their clinical significance is still unclear.
  • A study used advanced techniques to analyze DTCs and DTECs from 30 SCLC patients, including genetic sequencing to identify mutations in specific cell subtypes.
  • Findings showed higher levels of DTCs and DTECs compared to circulating tumor cells, with certain detections linked to poorer survival outcomes and lower effectiveness of treatment, emphasizing the importance of these cells in patient prognosis.
View Article and Find Full Text PDF

Clinicopathological and therapeutic comparisons of esophageal cancer between China and the USA: a multicenter hospital-based study.

J Natl Cancer Cent

December 2024

Office of National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Esophageal cancer (EC) remains a global health challenge due to its poor prognosis. China and the United States of America (USA) represent two distinct epicenters of EC burden. Understanding the EC disparities in these two countries is vital for tailoring prevention strategies, optimizing treatment, and enhancing outcomes in both countries.

View Article and Find Full Text PDF

Evaluation of Subetadex-α-methyl, a Polyanionic Cyclodextrin Scaffold, as a Medical Countermeasure against Fentanyl and Related Opioids.

ACS Cent Sci

December 2024

Physical and Life Sciences Directorate, Biosciences and Biotechnology Division, Global Security Directorate, Forensic Science Center, and Materials Science Division, Lawrence Livermore National Laboratory, Livermore, California 94550, United States.

Subetadex-α-methyl (SBX-Me), a modified, polyanionic cyclodextrin scaffold, has been evaluated for its utilization as a medical countermeasure (MCM) to neutralize the effects of fentanyl and related opioids. Initial toxicity assays demonstrate that SBX-Me has a nontoxic profile, comparable to the FDA-approved cyclodextrin-based drug Sugammadex. Pharmacokinetic analysis showed rapid clearance of SBX-Me with an elimination half-life of ∼7.

View Article and Find Full Text PDF

Introduction: The heart team approach is now the standard of care for patients with complex coronary artery disease; however, the definition of a heart team is variable. We embarked on a project to create an extended, multidisciplinary heart team to evaluate patients we deemed high risk for coronary revascularization. In doing so, we created a new service, workflow, and paradigm.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!