AI Article Synopsis
- The study developed poly(acrylic) acid (PAA)-based hydrogels using UV polymerization, which incorporated alginate to create an interpenetrating network structure.
- Adding nano-silica enhanced the hydrogels' compressive strength and toughness, while reducing cross-linking density and friction.
- The hydrogels demonstrated high water content (over 98%) and showed good compatibility with adipose stem cells, indicating their potential for use as artificial soft tissues.
Article Abstract
In this study, a series of poly(acrylic) acid (PAA)-based hydrogels was prepared by UV polymerization. Hydrogels with an interpenetrating network structure were formed by combining PAA and alginate (Alg) solutions. The incorporation of nano-silica into these gel solutions significantly increased their compressive strength and fracture toughness but lowered their cross-linking density and friction coefficient. The prepared hydrogels were considerably hydrophilic for water content greater than 98%, which is in accordance with the nature of soft tissues such as cartilage. The preliminary cell culture of adipose stem cells (ADSCs) on PAA-Alg-Si hydrogels results in good biological safety. These features suggest that the PAA-Alg-Si hydrogels prepared in this study can be used as artificial soft tissues.
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| http://dx.doi.org/10.1163/156856209X426448 | DOI Listing |
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