Grinding them down: By using a tailor-made additive, even in the absence of racemization in solution, abrasive grinding can yield an enantiopure solid state. This novel chiral resolution technique is based on an asymmetric bifurcation in the crystal size distribution as a result of stereoselective hampered crystal growth. R = o-tolyl.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1002/anie.200806214 | DOI Listing |
Food Chem
January 2025
Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, 138623, Singapore. Electronic address:
Oolong tea contains diverse isomers, such as amino acids. D-amino acids, compared with their L-enantiomers, exhibit distinct properties, influencing both the flavor and bioactivity of the tea. However, the analysis of these isomers remains challenging, especially the simultaneous determination of structural and chiral isomers.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
University of Basel, Department of Chemistry, St. Johanns-Ring 19, 4056, Basel, SWITZERLAND.
Despite the growing importance of planar chiral macrocyclophanes owing to their unique properties in different areas of chemistry, methods that are effective in controlling their planar chirality are restricted to certain molecular scaffolds. Herein, we report the first Pd(0)-catalyzed enantioselective intermolecular C-H arylation that induces planar chirality by installing bulky aryl groups through dynamic kinetic resolution (DKR). A computer-assisted approach allowed a fine-tuning of the structure of the employed chiral bifunctional phosphine-carboxylate ligands to achieve high enantioselectivities.
View Article and Find Full Text PDFJ Chromatogr A
January 2025
Chemistry Department, Faculty of Science, Taibah University, Yanbu, Saudi Arabia; Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt. Electronic address:
Indoprofen (INP) comprises two enantiomers, R- and S-, whose high pharmacological efficacy is realized only in the case of the separated enantiomers. A newly synthesized poly(acrylonitrile-co-divinylbenzene) (PANB)-based sorbent with selective affinity to the S-enantiomer of INP was applied to separate INP racemate. The synthesis was performed by suspension polymerization with low-crosslinked PANB microparticles and by reaction of the inserted nitriles with 1-amino-1H-pyrrole-2,5‑dione (Ma-NH).
View Article and Find Full Text PDFJ Chromatogr A
January 2025
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address:
Evodiamine, a chiral quinazoline alkaloid in the traditional Chinese medicine Evodiae fructus, exhibited efficacy for CNS diseases. In this study, the pure enantiomers of evodiamine were prepared in large quantities via chemical resolution. Their structures were elucidated by MS, NMR and ECD.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Shandong University, Department of Chemistry, 27 South Shanda Road, 250100, Jinan, CHINA.
Planar chirality found tremendous use in many fields, such as chemistry, optics, and materials science. In particular, planar chiral [2.2]paracyclophanes (PCPs) are a type of structurally interesting and practically useful chiral compounds bearing unique electronic and photophysical properties and thus have been widely used in π-stacking polymers, organic luminescent materials, and as a valuable toolbox for developing chiral ligands or organocatalysts.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!