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Acupuncture as an Adjunct Treatment in Stiff Person Syndrome.
Med Acupunct
October 2024
Department of Family Medicine, West Virginia University, Morgantown, West Virginia, USA.
Objective: Stiff person syndrome (SPS) is a rare neurological disorder. Treatments are limited, and non-pharmacologic therapies are recommended based on symptomatology. A G2P2002 post-menopausal 60-year-old female with hypertension, obesity, and type II diabetes, and SPS secondary to a paraneoplastic process cause by endometrioid ovarian adenocarcinoma who presented to acupuncture clinic seeking treatment for SPS and its sequela.
View Article and Find Full Text PDFParaneoplastic progressive encephalomyelitis with rigidity and myoclonus associated with monoclonal B-cell lymphocytosis in the setting of longstanding methotrexate use: case report.
Front Immunol
November 2024
Department of Neurology, Nepean Hospital, Kingswood, NSW, Australia.
Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare but debilitating disease within the stiff person syndrome (SPS) spectrum characterised by muscle rigidity, spasms, myoclonus, dysautonomia, and brainstem dysfunction. The exact pathogenetic mechanism is unclear, although there is an association with the presence of glycine receptor antibodies in serum and cerebrospinal fluid, and some cases are paraneoplastic. Here, we report a case of paraneoplastic, glycine receptor antibody-positive PERM associated with an otherwise subclinical monoclonal B-cell lymphocytosis (MBL) of the non-CLL phenotype, which may be, in turn, likely secondary to long-term methotrexate use [i.
View Article and Find Full Text PDFStiff-person syndrome.
Pract Neurol
January 2025
Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Article Synopsis
- * Symptoms arise from abnormal neuronal excitability due to disrupted GABA and glycine neurotransmission, and SPS can overlap with other autoimmune conditions such as autoimmune epilepsy and progressive encephalomyelitis.
- * Early diagnosis is crucial to prevent irreversible disabilities; the review provides insights into clinical signs that may indicate SPS, along with a diagnostic algorithm and treatment options including immunotherapy and GABA-ergic medications.
Effectiveness of Intravenous Cyclophosphamide in a Patient With Anti-amphiphysin Autoimmunity Presenting With Bulbar Palsy and Cerebellar Ataxia: A Case Report.
Cureus
July 2024
Department of Neurology, The Jikei University Katsushika Medical Center, Tokyo, JPN.
Anti-amphiphysin antibody is a rare paraneoplastic autoantibody. A case of a 74-year-old man with anti-amphiphysin antibody and multiple symptoms, including bulbar palsy along with cerebellar ataxia, who responded to treatment with intravenous cyclophosphamide is reported. The patient presented with progressive unsteady gait and difficulty in swallowing food and water for three months.
View Article and Find Full Text PDFExpanding the Understanding of Stiff-Person Syndrome: Insights from 17 Cases in India.
Ann Indian Acad Neurol
July 2024
Department of Neurology, University S.M.S Medical College and Hospital, Jaipur, Rajasthan, India.
Stiff-person syndrome (SPS) is a rare and complex neurologic disorder characterized by progressive muscle stiffness, painful spasms, and gait difficulties. In this report, we describe a case of SPS who presented with a relapse while on maintenance immunosuppressive treatment. In addition, we review the literature of 16 previously reported cases of SPS from India, highlighting the diverse clinical features, comorbidities, treatment response, and relapse.
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