In this Communication, the access to three different peptide loops attached to a small triazacyclophane (TAC) scaffold molecule for the mimicry of discontinuous epitopes present in, for example, antibodies is described for the first time.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/b817357e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predicting Immunogenic Epitopes Variation of Envelope 2 Gene Among Chikungunya Virus Clonal Lineages by an In Silico Approach.
Viruses
October 2024
Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Chikungunya virus (CHIKV), responsible for a mosquito-borne viral illness, has rapidly spread worldwide, posing a significant global health threat. In this study, we explored the immunogenic variability of CHIKV envelope 2 (E2), a pivotal component in the anti-CHIKV immune response, using an in silico approach. After extracting the representative sequence types of the CHIKV E2 antigen, we predicted the structure-based B-cell epitopes and MHC I and II binding T-cell epitopes.
View Article and Find Full Text PDFBioinformatics Analysis and Immunogenicity Assessment of the Novel Multi-Stage DNA Vaccine W541 Against Mycobacterium Tuberculosis.
Immun Inflamm Dis
November 2024
Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute of Tuberculosis Research, Senior Department of Tuberculosis, The Eighth Medical Center of PLA General Hospital, Beijing, China.
Background: Vaccination is one of the effective measures to prevent latent tuberculosis infection (LTBI) from developing into active tuberculosis (TB). Applying bioinformatics methods to pre-evaluate the biological characteristics and immunogenicity of vaccines can improve the efficiency of vaccine development.
Objectives: To evaluate the immunogenicity of TB vaccine W541 and to explore the application of bioinformatics technology in TB vaccine research.
Completing the pieces of a puzzle: in-depth probing of rhoptry protein 4 as a promising target for vaccination using an approach.
Clin Exp Vaccine Res
October 2024
Student Research Committee, Abadan University of Medical Sciences, Abadan, Iran.
The present study aimed to evaluate the key characteristics of rhoptry protein 4 (TgROP4), including physicochemical parameters, structural features, immunogenic epitopes, and virtual immune simulation, using several bioinformatics-based servers and tools. Based on allergenicity and antigenicity outputs, the TgROP4 protein seemed to have an immunogenic and non-allergenic nature. The quality of the three-dimensional (3D) structure improved after refinement, according to the outcomes of the Ramachandran plot and the ProSA-web servers.
View Article and Find Full Text PDFStructural insights into epitope-paratope interactions of a monoclonal antibody targeting CEACAM5-expressing tumors.
Nat Commun
October 2024
Integrated Drug Discovery, Sanofi R&D, Paris, France.
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are overexpressed in some tumor types. The antibody-drug conjugate tusamitamab ravtansine specifically recognizes the A3-B3 domains of human CEACAM5 (hCEACAM5). To understand this specificity, here we map the epitope-paratope interface between the A3-B3 domains of hCEACAM5 (hCEACAM5) and the antigen-binding fragment of tusamitamab (tusa Fab).
View Article and Find Full Text PDFHERV-Derived Syncytin-1 and Syncytin-2 as Sources of Linear and Discontinuous Epitopes in Antiphospholipid Syndrome: A Pivotal Computational Study.
Discov Med
October 2024
Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, University Hospital "G. Martino", 98125 Messina, Italy.
Article Synopsis
- This study explores the potential link between human endogenous retroviruses (HERVs), specifically syncytin-1 and syncytin-2, and the development of antiphospholipid syndrome (APS).
- Researchers used computational tools to predict T-cell and B-cell epitopes from these syncytins and a reference protein, β2-glycoprotein I, to assess their ability to trigger an immune response in genetically susceptible individuals.
- The findings indicate that syncytin-1 has a higher number of immunogenic epitopes and binding affinity than syncytin-2, suggesting that HERVs could play a role in APS development, but more lab studies are needed to confirm this.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!