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Temperature Regulates Astroglia Morphogenesis Through Thermosensory Circuitry in Caenorhabditis elegans.
Glia
January 2025
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Astrocytes are the most abundant type of macroglia in the brain and play crucial roles in regulating neural development and functions. The diverse functions of astrocytes are largely determined by their morphology, which is regulated by genetic and environmental factors. However, whether and how the astrocyte morphology is affected by temperature remains largely unknown.
View Article and Find Full Text PDFAberrant neuronal hyperactivation causes an age-dependent behavioral decline in .
Proc Natl Acad Sci U S A
January 2025
Group of Microbial Motility, Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Age-dependent sensory impairment, memory loss, and cognitive decline are generally attributed to neuron loss, synaptic dysfunction, and decreased neuronal activities over time. Concurrently, increased neuronal activity is reported in humans and other organisms during aging. However, it is unclear whether neuronal hyperactivity is the cause of cognitive impairment or a compensatory mechanism of circuit dysfunction.
View Article and Find Full Text PDFThe antibacterial and antibiofilm role of cannabidiol against periodontopathogenic bacteria.
J Appl Microbiol
January 2025
Laboratory of Antimicrobial Testing (LEA), Institute of Biomedical Sciences (ICBM), Universidade Federal de Uberlândia (UFU), Uberlândia, MG 38405-320, Brazil.
Aims: Bacterial resistance and systemic risks associated with periodontitis underscore the need for novel antimicrobial agents. Cannabis sativa is a promising source of antimicrobial molecules, and cannabidiol (CBD) attracts significant interest. This study evaluated the antibacterial and antibiofilm activity of CBD against periodontopathogens, and assessed its toxicity in vivo model.
View Article and Find Full Text PDFThe usefulness of C. elegans life span analysis in screening for functional foods.
Biosci Biotechnol Biochem
November 2024
Tokai University, Department of Health Management, Undergraduate School of Health Studies, 4-1-1 Kitakaname, Hiratsuka-shi, Kanagawa Japan.
Caenorhabditis elegans is a type of nematode that has significantly contributed to aging research as a multicellular animal model because of its high reproductive rate, ease of cultivation, low cost, short generation cycle, body transparency, and eukaryotic nature. Since the discovery of long-lived mutant strains of C. elegans, signaling pathways involved in lifespan have been elucidated.
View Article and Find Full Text PDFUPR-immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food.
Elife
September 2024
Southwest United Graduate School,Yunnan Key Laboratory of Cell Metabolism and Diseases, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China.
To survive in challenging environments, animals must develop a system to assess food quality and adjust their feeding behavior accordingly. However, the mechanisms that regulate this chronic physiological food evaluation system, which monitors specific nutrients from ingested food and influences food-response behavior, are still not fully understood. Here, we established a low-quality food evaluation assay system and found that heat-killed (HK- a low-sugar food, triggers cellular UPR and immune response.
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