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Revisiting surfactant protein D: an immune surveillance molecule bridging innate and adaptive immunity.
Front Immunol
January 2025
Department Integrative Agriculture, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, United Arab Emirates.
Surfactant protein D (SP-D) is a C-type lectin that was originally discovered as a lung surfactant associated phospholipid recognising protein. It was originally shown to be of great importance in surfactant turnover and homeostasis in conjunction with another hydrophilic surfactant protein i.e.
View Article and Find Full Text PDFThe evolution of nutritional care in children with food allergies - With a focus on cow's milk allergy.
J Hum Nutr Diet
February 2025
Section of Allergy and Immunology, University of Colorado/Children's Hospital Colorado, Boulder, Colorado, USA.
Cow's milk allergy (CMA) remains one of the most common and complex paediatric food allergies. In the last decade, our understanding has advanced in terms of immunoglobulin E (IgE)-mediated CMA and focus is now also paid to non-IgE-mediated CMA, particularly in some Western countries where incidence rates are high. We have had significant progress in the last 10 years in relation to our understanding of existing supportive tests for IgE-mediated CMA, with the advancement of newer tests, such as the basophil activation test (BAT), which have shown great promise.
View Article and Find Full Text PDFDupilumab combined with corticosteroid therapy for Kimura disease with multiple systemic masses: a case report and literature review.
Front Immunol
November 2024
Department of Dermatology, Shenzhen University General Hospital, Shenzhen, Shenzhen, China.
Article Synopsis
- Kimura's disease (KD) is a rare condition with unclear causes, no standardized diagnostic criteria, and varied clinical presentations, leading to ongoing research for optimal treatment strategies.
- The paper discusses a case of a 37-year-old Chinese woman who experienced 12 years of skin issues and limb swelling before being diagnosed with KD, resulting in a specific treatment plan combining dupilumab and oral corticosteroids.
- After treatment, the patient had significant improvements with reduced nodules and lower levels of serum IgE, eosinophils, and basophils, indicating the effectiveness of the combined therapy for KD and concurrent atopic dermatitis.
Investigation of the diagnostic accuracy of basophil activation test for allergic phenotypes of rhinitis.
Allergy
November 2024
Allergy Unit, Hospital Regional Universitario de Malaga, Malaga, Spain.
Article Synopsis
- The study explores the potential of the Basophil Activation Test (BAT) as a replacement for the Nasal Allergen Challenge (NAC) in diagnosing different types of rhinitis due to allergies.
- It involved testing rhinitis patients with various allergens and analyzing the results of BAT alongside traditional skin prick tests to categorize patients into allergic and non-allergic phenotypes.
- Findings suggest BAT has a high ability to confirm allergic rhinitis, especially in patients with positive skin prick tests, while also identifying cases of allergy in patients who test negative on skin prick tests.
Essential mineral elements in roe deer: Associations with parasites and immune phenotypes in two contrasting populations.
Ecol Evol
October 2024
Université de Lyon, VetAgro Sup - Campus Vétérinaire de Lyon, Laboratoire de Parasitologie Vétérinaire Marcy-L'Etoile France.
Low levels of essential mineral elements such as cobalt, copper, and iron, in organisms reduce immune function, increasing the chances of parasitic infection. This phenomenon has been demonstrated widely in domestic animals but rarely in wildlife. In this study, we used data from 7- to 9-month-old roe deer (), living in two different populations facing contrasting environmental conditions (Trois-Fontaines and Chizé), to investigate whether the parasitic and immunological statuses could be related to essential element status.
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