Purpose: This is a case study of Fusarium keratitis progressing to endophthatmitis that was successfully treated with a tiposomal formulation of amphotericin B (AmBisome] and local natamycin 5%.
Methods: A 41-year-old man presented with a clinical picture of endophthalmitis following deep Fusarium solani keratitis. Treatment with natamycin 5% drops and intravenous amphotericin B 150 mg per day caused renal failure and did not alleviate the endophthalmitis. Therefore, intravenous amphotericin B was replaced with intravenous AmBisome, 300 mg per day, to a cumulative dosage of 5.4 g.
Results: Both the endophthalmitis and keratitis were alleviated within several weeks after starting AmBisome treatment. No systemic toxicity was noted. The final ophthalmoLogic examination showed a paracentral corneal scar, and a satisfactory best corrected visual acuity of 20/40.
Conclusions: Due to their relatively low systemic toxicity, liposomal formulations of amphotericin B can be administered in higher doses than traditional unencapsulated ntravenous amphotericin B achieving higher concentrations in the target organ.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Stability enhancement of Amphotericin B using 3D printed biomimetic polymeric corneal patch to treat fungal infections.
Int J Pharm
December 2024
Translational Pharmaceutics Research Laboratory (TPRL), Department of Pharmacy, Birla Institute of Technology and Sciences (BITS), Pilani, Hyderabad Campus, Hyderabad, Telangana 500078, India. Electronic address:
Amphotericin B eye drops (reconstituted from lyophilized Amphotericin B formulation indicated for intravenous use) is used off-label for fungal keratitis. However, the reconstituted formulation is stable only for a week, even after refrigeration. Moreover, a high dosing frequency makes it an inconvenient treatment practice.
View Article and Find Full Text PDFTHE EFFECT OF VITAMIN D ON THE HISTOLOGICAL STRUCTURE OF LIVER AND LUNG IN MICE TREATED WITH AMPHOTERICIN B.
Georgian Med News
October 2024
3Department of Biology, College of Education for Pure Science, University of Mosul, Ninevah, Iraq.
The aim of this work is to investigate the effects of L-AMB (Amphociene) on liver and lung tissues in adult mice, and the role of vitamin D3 in reducing its side effects. Amphotericin B (AMB), a polyene macrolide antibiotic, is used to treat serious fungal infections and leishmaniasis. It may cause increased serum aminotransferase and hyperbilirubinemia due to interference with hepatic cytochrome P450.
View Article and Find Full Text PDFCase report of antifungal drug-induced phlebitis in a patient with myelodysplastic syndrome.
Medicine (Baltimore)
December 2024
Department of Hematology and Oncology, International Cancer Center, Shenzhen Key Laboratory, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University Health Science Center, Shenzhen, China.
Rationale: This article summarized the nursing experience of phlebitis caused by intravenous infusion of amphotericin B cholesterol sulfate complex in a patient with myelodysplastic syndrome.
Patient Concerns: A 59-year-old man with myelodysplastic syndrome complicated with fungal infection was treated with antifungal therapy.
Diagnoses: Patient with myelodysplastic syndrome was diagnosed with secondary phlebitis caused by liposomal amphotericin B.
Effects of Different Concentrations of AmB on the Unsaturated Phospholipid-Cholesterol Membrane Using the Langmuir Monolayer and Liposome Models.
Molecules
November 2024
Xi'an Key Laboratory of Advanced Photo-Electronics Materials and Energy Conversion Device, School of Electronic Information, Xijing University, Xi'an 710123, China.
Amphotericin B (AmB) causes toxicity to the erythrocyte membrane, leading to hemolysis, which limits the clinically effective dose for AmB intravenous therapy in invasive fungal infections. The molecular mechanism by which AmB adheres to the membrane of erythrocytes is the key factor in causing AmB to be toxic to the membrane of erythrocytes, but it is not yet fully understood; the mechanism by which AmB adheres to the liquid microdomains with higher fluidity formed by cholesterol and unsaturated phospholipids remains especially unclear. This study examined the adsorption of AmB at different concentrations, 5, 45, 85, and 125 μg/mL, on unsaturated phospholipid membranes containing 50 mol% cholesterol.
View Article and Find Full Text PDFRhino-Orbital Mucormycosis Presenting As Orbital Apex Syndrome With Central Retinal Artery Occlusion: A Rare Phenomenon.
Cureus
November 2024
Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MYS.
Rhino-orbital-cerebral mucormycosis (ROCM) is an opportunistic infection that has increased due to COVID-19 with the use of corticosteroids and diabetes being the most important predisposing factors. Orbital apex syndrome with central retinal artery occlusion secondary to mucormycosis is relatively rare. This case report highlights a case of a 62-year-old female with poorly controlled diabetes and a history of COVID-19 two weeks prior, who presented with acute right eye painful visual loss for three days associated with bulging of the right eye and drooping of the eyelid.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!