This is Part II of four parts describing the three-step principle being applied in reconstructive and aesthetic breast surgery. Part I explains how to analyze a problematic breast by understanding the main anatomical features of a breast and how they interact: the footprint, the conus of the breast, and the skin envelope. This part describes how one can optimize results with breast reconstructions after complete mastectomy. For both primary and secondary reconstructions, the authors explain how to analyze the mastectomized breast and the deformed chest wall, before giving step-by-step guidelines for rebuilding the entire breast with either autologous tissue or implants. The differences in shaping unilateral or bilateral breast reconstructions with autologous tissue are clarified. Regardless of timing or method of reconstruction, it is shown that by breaking down the surgical strategy into three easy (anatomical) steps, the reconstructive surgeon will be able to provide more aesthetically pleasing and reproducible results. Throughout these four parts, the three-step principle will be the red line on which to fall back to define the problem and to propose a solution.
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http://dx.doi.org/10.1097/PRS.0b013e318199ef16 | DOI Listing |
Advances in personalized medicine and Systems Biology have introduced probabilistic models and error discovery to cardiovascular care, aiding disease prevention and procedural planning. However, clinical application faces cultural, technical, and methodological hurdles. Patient autonomy remains essential, with shared decision-making (SDM) gaining importance in managing complex cardiovascular treatment options.
View Article and Find Full Text PDFAs an advanced nucleic acid therapeutical modality, mRNA can express any type of protein in principle and thus holds great potential to prevent and treat various diseases. Despite the success in COVID-19 mRNA vaccines, direct local delivery of mRNA into the lung by inhalation would greatly reinforce the treatment of pulmonary pathogens and diseases. Herein, we developed lipid nanoparticles (LNPs) from degradable ionizable glycerolipids for potent pulmonary mRNA delivery via nebulization.
View Article and Find Full Text PDFAcc Chem Res
January 2025
College of Chemistry, Sichuan University, Chengdu 610065, P. R. China.
Small
November 2024
Department of Physics, Indian Institute of Technology, Hauz Khas, New Delhi, 110016, India.
The molybdenum disulfide-praseodymium sulfide (MoS-PrS) heterojunctions are optimally synthesized through a sophisticated three-step procedure. Initially, MoS rods are synthesized using the micellar route followed by a solid-state reaction, forming well-defined structures. Subsequently, PrS nanoparticles are synthesized using the same method.
View Article and Find Full Text PDFAnn Chir Plast Esthet
November 2024
Service de chirurgie plastique, reconstructrice et esthétique, hôpital de la Croix-Rousse, hospices civils de Lyon, 103, Grande rue de la Croix-Rousse, 69004 Lyon, France; Faculté de médecine Lyon Est, université Claude-Bernard Lyon 1, 8, avenue Rockefeller, 69003 Lyon, France.
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