AI Article Synopsis
- The recognition of nucleic acid bases in DNA is essential for genetic information transfer, influencing everything from protein assembly to evolution.
- Chemists are now creating synthetic bases and pairing structures that mimic DNA's function, moving beyond natural bases.
- Recent studies show these synthetic bases can self-assemble and even replicate within bacterial cells, indicating a potential for redesigning the genetic information in living organisms while maintaining their biological functions.
Article Abstract
Recognition of the nucleic acid bases within the DNA scaffold comprises the basis for transmission of genetic information, dictating protein and cell assembly, organismal development, and evolution. Driven in part by the need to test our current understanding of this information transfer, chemists have begun to design and synthesize nonnatural bases and base pair structures to mimic the function of DNA without relying on Nature's purine-pyrimidine base pair scaffold. Multiple examples have been recently described that self-assemble stably and sequence specifically in vitro, and some isolated unnatural base pairs can be replicated in vitro as well. Moreover, recent experiments with unnatural bases in bacterial cells have demonstrated surprisingly efficient reading of the chemical information. This suggests the future possibility of redesigning and replacing the chemical information of an evolving cell while retaining biological function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693216 | PMC |
| http://dx.doi.org/10.1016/j.chembiol.2008.12.004 | DOI Listing |
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