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Phthalates (PAEs) are endocrine-disrupting chemicals that are widely present in everyday life and enter the human body through various pathways. The release of PAEs into the environment through pathways that include leaching, evaporation, abrasion, and the use of personal care products exposes humans to PAEs via ingestion, inhalation, and dermal absorption. Pregnant women, as a particularly vulnerable population, risk adverse newborn growth and development when exposed to PAEs.
View Article and Find Full Text PDFFast and reliable method for analysis of derivatized plasma amino acids by liquid chromatography-single quadrupole-mass spectrometry.
JDS Commun
November 2024
Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706.
The pool of free, genetically encoded AA in plasma plays an essential role not only as substrate for every protein synthesized in the body but also as signaling molecules that regulate a wide range of physiological processes. Here we present a method for the analysis of 19 of the 20 encoded AA (except Cys) in dairy cow plasma. Isolated plasma or standards for the 19 AA were gravimetrically mixed with an internal standard mix consisting of C isotopes of each AA.
View Article and Find Full Text PDFCortisol quantification in human plasma and urine by liquid chromatography coupled to mass spectrometry: Validation, analysis and application in a reference population and patients with adrenal incidentalomas.
Clin Chim Acta
January 2025
Federal University of Rio de Janeiro - UFRJ, Brazilian Doping Control Laboratory - LBCD, LADETEC, Av. Horácio Macedo, 1281 - Polo de Química - Bloco C - Cidade Universitária - Ιlha do Fundão, Rio de Janeiro, Brazil.
Article Synopsis
- Cortisol is a crucial hormone involved in various bodily processes, but traditional immunoassays can inaccurately measure it due to low specificity.
- The study developed and validated advanced LC-MS/MS methods for accurately measuring cortisol in urine and plasma samples, adhering to Brazilian health regulations.
- Their methods demonstrated high precision and sensitivity, successfully analyzing samples from patients at a major hospital in Rio de Janeiro.
Design-assisted HPLC-UV method for therapeutic drug monitoring of pholcodine, ephedrine, and guaifenesin in biological fluids.
Sci Rep
November 2024
Department of Pharmaceutical Analytical Chemistry Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt.
Drug-drug interactions may amplify or diminish their intended effects, or even produce entirely new effects. Multicomponent mixture HPLC analysis offers a thorough and effective method for comprehending the makeup and behavior of complicated materials, advancing research and development across a range of scientific and industrial domains. A novel experimental design-assisted HPLC methodology for the concurrent investigation of the drug-drug interaction of pholcodine, ephedrine, and guaifenesin in biological fluids has been established.
View Article and Find Full Text PDFDevelopment of a disposable paper-based thin film solid-phase microextraction sampling kit to quantify ketone body.
RSC Adv
October 2024
Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education Manipal Karnataka 576104 India
Article Synopsis
- Diabetes ketoacidosis (DKA) is a serious condition primarily affecting individuals with type 1 diabetes, leading to acidic blood and disrupted metabolism due to excess ketones.
- The study discusses a new diagnostic method using a paper-based patch that employs thin film solid-phase microextraction (TF-SPME) to improve the detection of β-hydroxybutyric acid (BHB), a key ketone body.
- Results show that the paper patches made with DVB/PDMS have better extraction efficiency for BHB than other materials tested, offering a highly accurate and straightforward quantification method for this important biomarker.
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