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Molecular basis of human angiotensin-1 converting enzyme inhibition by a series of diprolyl-derived compounds.
FEBS J
January 2025
Department of Life Sciences, University of Bath, UK.
Angiotensin-1-converting enzyme (ACE) is a zinc-dependent carboxypeptidase of therapeutic interest for the treatment of hypertension, inflammation and fibrosis. It consists of two homologous N and C catalytic domains, nACE and cACE, respectively. Unfortunately, the current clinically available ACE inhibitors produce undesirable side effects due to the nonselective inhibition of these domains.
View Article and Find Full Text PDFDesign optimization of a 1-D array of stemless plastic scintillation detectors.
Med Phys
January 2025
Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada.
Background: A stemless plastic scintillation detector (SPSD) is composed of an organic plastic scintillator coupled to an organic photodiode. Previous research has shown that SPSDs are ideally suited to challenging dosimetry measurements such as output factors and profiles in small fields. Lacking from the current literature is a systematic effort to optimize the performance of the photodiode component of the detector.
View Article and Find Full Text PDFCopper Prevention Values in Brazilian Subtropical Soils.
Chemosphere
January 2025
Santa Catarina State University, Center for Higher Education of the West, Department of Animal Science, Chapecó, Santa Catarina, Brazil. Electronic address:
The Brazilian National Environmental Council (CONAMA) Resolution 420/2009 establishes soil quality guideline values for copper, as the prevention value (PV). It defines the maximum concentrations of chemical substances permitted in the soil. Thus, the aim of the present research was to evaluate the effectiveness of the copper PV adopted at the national level by conducting exposure assays with enchytraeids (Enchytraeus crypticus, Enchytraeus bigeminus and Enchytraeus dudichi) and springtails (Folsomia candida, Proisotoma minuta and Sinella curviseta) in two Brazilian subtropical soils: a Latosol and an Argisol.
View Article and Find Full Text PDFBackground: Tooth wear is an important mechanism for reducing dental dimensions and, consequently, dental crowding. The objective of this cohort study was to examine the relation of tooth wear, adjusted for covariates (age, tooth loss, arch perimeter and intercanine width), on tertiary crowding in Amazon Indigenous populations.
Methods: A sample of 40 Indigenous people in permanent dentition at T0 (baseline) and after 13 years (T1) were evaluated.
Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data.
Nat Commun
January 2025
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Spatial protein expression technologies can map cellular content and organization by simultaneously quantifying the expression of >40 proteins at subcellular resolution within intact tissue sections and cell lines. However, necessary image segmentation to single cells is challenging and error prone, easily confounding the interpretation of cellular phenotypes and cell clusters. To address these limitations, we present STARLING, a probabilistic machine learning model designed to quantify cell populations from spatial protein expression data while accounting for segmentation errors.
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