AI Article Synopsis
- The study explored how tyloxapol, a surfactant, affects the chromatographic separation of important biomedical compounds like organic acids, amino acids, and drugs.
- Factors such as tyloxapol concentration, organic modifier content, and pH were examined to see their impact on solute retention.
- Results highlighted differences in chromatographic behavior between tyloxapol and Triton X-100 due to variations in their physical and chemical properties, such as microviscosity and micelle shape.
Article Abstract
The chromatographic behavior of model compounds of biomedical significance (organic acids, amino acids, drugs) was investigated using mobile phases modified with tyloxapol. The influence of factors such as concentration of tyloxapol, content of organic modifier and pH of mobile phase on the retention factor of solutes was studied. The results were compared with the data obtained by elution with mobile phases containing Triton X-100 additives, since units of Triton X-100 are repeated in the structure of tyloxapol. Divergence in chromatographic behavior of model compounds was explained by the difference in physico-chemical characteristics (microviscosity, polarity, critical micelle concentration, shape of micelles, etc.) of tyloxapol and Triton X-100 micelles.
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| http://dx.doi.org/10.1002/bmc.1166 | DOI Listing |
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