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Evaluation of antioxidant properties of monoaromatic derivatives of pulvinic acids. | LitMetric

Evaluation of antioxidant properties of monoaromatic derivatives of pulvinic acids.

J Med Chem

Laboratoire de Synthese Bio-Organique, CNRS-UMR 7175/LC1, Institut Gilbert Laustriat, Faculte de Pharmacie, Illkirch, 67401 France.

Published: April 2009

AI Article Synopsis

  • - The study explores the antioxidant properties of Norbadione A and three other pulvinic acids, which outperform many known antioxidants like catechols and flavonoids.
  • - Researchers synthesized 18 pulvinic acid derivatives and assessed their ability to scavenge radicals through four different assays to understand how structural components influence their antioxidant activity.
  • - The findings suggest that these compounds not only demonstrate strong antioxidant effects but also show no cytotoxicity, indicating potential for use in anti-inflammatory applications and skin protection from UV damage.

Article Abstract

The natural mushroom pigment Norbadione A and three other pulvinic acids were shown by our group to display very efficient antioxidant properties by comparison with a collection of potent molecules including catechols, flavonoids, stilbenes, or coumarins. Despite numerous publications on robust and straightforward synthetic access to pulvinic acids by us and others, no report has been made to unravel the structure-activity relationships that govern the striking antioxidant activity. Herein is presented the synthesis of 18 diverse pulvinic acid derivatives and the study of their radical scavenging capacities by four different assays. The influence of each of the two phenyl rings, of their substituents and of the lateral chain on the antioxidant properties, was explored to reveal a simplified structure of excellent activity. These results, along with the absence of cytotoxicity, make the synthesized compounds interesting to evaluate for several biological activities and especially for anti-inflammatory effects and skin protection against UV induced oxidative stress.

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Source
http://dx.doi.org/10.1021/jm801500hDOI Listing

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